The content of ascorbic acid in the liver and adrenal glands of rats during correction of alimentary hypothyrosis by an iodine of a different chemical nature

Authors

  • O. I. Ryabukha Lviv Medical Institute

DOI:

https://doi.org/10.11603/mcch.2410-681X.2018.v0.i1.8841

Keywords:

hypothyrosis, ascorbic acid, organic iodine, inorganic iodine, liver, adrenal glands.

Abstract

Introduction. Metabolisms of vitamins, trace elements and hormones are closely linked. The connection between  ascorbic acid and hormones, in particular derivatives of tyrosine and steroids, determines its importance for the activity of the thyroid gland, adrenal glands and liver. The most common thyroid pathology is hypothyroidism, caused by iodine deficiency. For its treatment and prevention, compounds that contain iodine of different chemical nature are used.


The aim of the study – to compare the effect of the action of organic and inorganic iodine on the content of ascorbic acid (AA) in the liver and adrenal glands.


Research Methods. The study was conducted in the model conditions of alimentary hypothyroidism on 80 white nonlinear male rats weighing 0.140–0.160 kg, which for 30 days were in an isocaloric starch-casein ration. Adjustment of iodine deficiency was carried out on three doses of iodine (21, 50, 100 μg/kg body weight), which animals uptaked with potassium iodide (inorganic iodine) and iodine-protein preparation from the Black Sea industrial red algae of Phyllophora nervosa (DС.) Grev (organic iodine). The content of AA in the tissues was determined using Tillman’s reagent.


Results and Discussion. In conditions of alimentary hypothyroidism, the level of AA in the investigated organs was significantly reduced, which may indicate a decrease in the activity of metabolic processes. The consumption of both iodine-containing substances at a dose of 21 μg/kg was accompanied by a probable increase in the content of AА in the liver. Under the influence of 50 μg/kg iodine, its level in the rat’s liver and adrenal glands reached the levels of intact rats, but under use organic iodine the level of AA was higher. When receiving 100 μg/kg of iodine, the content of AA in organs was significantly reduced relative to the achieved parameters and in the adrenal glands was at the level of parameters of rats that did not consume iodine-containing compounds.


Conclusions. The intake of both inorganic and organic iodine contribute to an increase in the content of AA in the liver and adrenal glands, which is a prerequisite for activating the activity of the thyroid gland, while the effect of organic iodine is more powerful. The effect of both iodine-containing preparations on the liver is greater, which may be a sign of its greater sensitivity to the strengthening of thyroid hormonepoise and indicate an increase in its metabolic activity.

References

Rebrov, V.G., & Gromova, O.A. (2008). Vitaminy, makro- i mikroelementy [Vitamins, macro- and microelements]. Moscow: GEOTAR-Media [in Russian].

Timirkhanova, G.A., Abdullina, G.M., & Kulagina, I.G. (2007). Vitamin C: klassicheskie predstavleniya i novye fakty o mekhanizmakh biologicheskogo deystviya [Vitamin C: classical conceptions and new facts aboutthe mechanisms of biological action]. Vyatskiy meditsinskiy vestnik – Vyatsky Medical Bulletin, 4, 158-161 [in Russian].

Naidu, K.A. (2003). Vitamin C in human health and disease is still a mystery? An overview. Nutrition Journal, 2, 7. ttps://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-2-7

Blomhoff, R. (2005). Dietary antioxidants and cardiovascular disease. Current Opinion in Lipidology, 16, 47-54.

Walingo, K.M. (2005). Role of vitamin C (ascorbic acid) on human health - A review. African Journal of Food, Agriculture, Nutrition and Development (AJFAND), 5 (1). https://tspace.library.utoronto.ca/bitstream/1807/7699/1/nd05011.pdf

Figueroa-Méndez, R., & Rivas-Arancibia, S. (2015). Vitamin C in health and disease: its role in the metabolism of cells and redox state in the brain [Internet]. Frontiers in Physiology, 6, 397, doi: 10.3389/fphys.2015.00397

Osama, A., & Ahmed, R.G. (2017). Hypothyroidism. In D. Springer (Ed.). A New Look At Hypothyroidism (pp. 1-20). Rijeka, Croatia:InTech.

Stortoni, P., & Tranquilli, A.L. (2013). Hypothyroidism, fertility and pregnancy. In E. Potluková (Ed.). Current topics in hypothyroidism with focus on development (pp. 3-27). Rijeka, Croatia: InTech.

Gorodetskaya, I.V., Gusakova, E.A., & Evdokimova, O.V. (2016). Perifericheskie mekhanizmy stressprotektornogo ehffekta yodsoderzhashchikh gormonov shchitovidnoy zhelezy [Peripheral mechanisms of the stressprotective effect of iodine-containing thyroid hormones]. Vestnik VGMU – Journal of Vitebsk State Medical University, 15 (6), 41-53 [in Russian].

Glinoer, D. (2004). Pregnancy and iodine. Thyroid, 11 (5), 471-481.

Akopian, H.R., Osadchuk, Z.V., Kitsera, N.I., Chaikovska, H.S., Kovaliv, I.B., Kostsyk, N.R., … Viitovych, I.V. (2004). Selektyvnyi skryninh urodzhenoho hipotyreozu u ditei iz zatrymkoiu rozumovoho rozvytku

[Selective screening of congenital thyroid deficiency in children with mental retardation]. Bukovynskyi medychnyi visnyk – Bukovyna Medical Journal, 8 (3-4), 119-122 [in Ukrainian].

Mamenko, M.Ye. (2013). Yodnyi defitsyt ta yododefitsytni zakhvoriuvannia [Iodine deficiency and iodine deficiency disorders]. Perinatolohiia i pediatriia – Perinatology and Pediatrics, 1(53), 97-105 [in Ukrainian].

Mokhort, T.V., Kolomiets, N.D., Petrenko, S.V., Fedorenko, Yе.V., & Mokhort, Yе.G. (2015). Yodnyy defitsit: gde my teper? (Effektivnost belorusskoy strategii likvidatsii yodnogo defitsita: 15-letniy opyt) [Iodine deficiency: where are we now? (Efficiency of Belarusian strategy in elimination of iodine deficiency: 15-year experience)]. Mezhdunarodnyy endokrinologicheskiy zhurnal – International Endocrinology Journal, 2 (66), 13-19 [in Russian].

Zimmermann, M.B. (2009). Iodine deficiency.docrine Reviews, 30(4), 376-408.

Bolshakova, L.S., Litvinova, E.V., Kuzina, A.V., Lisiyn, A.B., & Chernuha, I.M. (2013). Исследование профилактической эффективности Биологически активной добавки биойод [Study of prophylactic effectiveness of the biologicalski active additives bioiod]. Fundamentalnyye issledovaniya –Fundamental Researches, 10/11, 2401-2404 [in Russian].

Tsyb, A.F., Tutelyan, V.A., Onishchenko, G.G., Shakhtarin, V.V., Parshyn, V.S., Roziyev, R.A., ... Proshyn, A.D. (2004). Novyye podkhody v reshenii problemy likvidatsii yoddefitsitnykh sostoyaniy [New approaches for solution of the problem of iodine deficiency state liquidation]. Dovkillia ta zdorovia – Environment & Health,3, 66-69 [in Russian].

Riabukha, O. (2015). Application of new information technologies for the study of cell activity. In Proceedings of the XIth International Conference - MEMSTECH’ 2015 (IEEE Cat. No. CFP1564A-PRT), 69-71. Sept. 2-6, Lviv-Poliana, Ukraine. http://www.worldcat.org/ title/application-of-new-information-technologies-for-thestudyof-cell-activityoclc/5912679282&referer=brief_results#reviews

Riabukha, O.І. (2017). Ultrastrukturni osoblyvosti syntetychnoi diialnosi folikuliarnykh tyrotsytiv pry pryimanni orhanichnoho yodu v umovakh alimentarnoho yododefitsytu [Ultrastructural features of the follicular thyrocytes synthetic activity while taking organic iodineunder conditions of alimentary iodine deficiency]. Visnyk problem biolohii i medytsyny – Bulletin of Problems in Biology and Medicine, 4, 2(140), 134-139 [in Ukrainian].

Riabukha, O.І. (2017). Doslidzenia syntetychnoi diialnosti folikuliarnykh tyrotsytiv pry pryimanni neorhanichnoho yodu v umovakh alimentarnoho yododefitsytu [Study of the follicular thyrocytes synthetic activity while taking inorganic iodine under conditions of alimentary iodine deficiency]. Visnyk problem biolohii i medytsyny – Bulletin of Problems in Biology and Medicine, 4, 3 (141), 218-223, doi: 10.29254/2077–4214–2017–4–3–141–218-223 [in Ukrainian].

Riabukha, O.І. (2018). Masa tila yak pokaznyk zahalnoho stanu orhanizmu pry pryimanni yodu orhanichnoi i neorhanichnoi khimichnoi pryrody v umovakh optymalnoho zabezpechennia yodom [Body weight as an indicator of the organism’s general condition while receiving iodine of organic and inorganic chemical origin under conditions of the optimal iodine supplementing]. Visnyk problem biolohii i medytsyny – Bulletin of Problems in Biology and Medicine, 1, 1(142), 97-102, doi: 10.29254/2077–4214–2018–1–1–142–97-102 [in

Ukrainian].

Turianica, I., Rostoka, L., Balint, L., Hluchy, S., & Kulcicky, O. (2009). Iodide insufficiency – consequences and prophylaxis. Zootehnie şi Biotehnologii, 42 (1), 300-322.

Plashchevaya, E.V., Smirnov, V.A., Nigej, N.V., & Lysak, V.A. (2014). Veroyatnostnyy metod diagnostiki v meditsine. Osnovnye vidy vrachebnoy logiki [Probabilistic method of diagnosis in medicine. The main types of medical logic]. In Posobie dlya prakticheskih zanyatij po medicinskoj informatike [Manual for practical training in medical informatics] (p.176). Blagoveshchensk: AGMA [in Russian].

Tohei, A. (2004). Studies on the functional relationship between thyroid, adrenal and gonadal hormones. Journal of Reproduction and Development, 50 (1), 9-20.

Seike, M. (2016). Endocrine Disease and Liver. In H. Ohira (Ed.). The Liver in Systemic Diseases (pp. 251-270). Tokyo: Springer.

Published

2018-05-03

How to Cite

Ryabukha, O. I. (2018). The content of ascorbic acid in the liver and adrenal glands of rats during correction of alimentary hypothyrosis by an iodine of a different chemical nature. Medical and Clinical Chemistry, (1), 51–59. https://doi.org/10.11603/mcch.2410-681X.2018.v0.i1.8841

Issue

Section

ORIGINAL INVESTIGATIONS