Roleofgasotransmitters: nitrogen oxide and hydrogen sulfide in smool intestine of rats under cyclooxygenase and lipoxygenase inhibition

  • Yu. O. Sklyarova
  • N. V. Denysenko
  • I. I. Ilkiv
  • I. S. Fomenko
Keywords: Cyclooxygenase, lipoxygenase, nitrogenoxide, hydrogensulfide, mucosa of small intestine.

Abstract

Inexperimentstherewerecomparedthecyclooxygenaseinhibitionbyindomethacinanddualcycloocygenaseandlipoxygenaseblockageby 4-thiazolidinonederivatives, capabletoreleasehydrogensulfidein small intestine. Itwasshownthatindomethacinwasaccompaniedbytheformationoflesions in the distal part ofsmall intestine, significantactivationofinducibleNO-synthase, thedecreaseofH2Sproduction, riseinmalonicdialdehydeconcentrationand activity of myeloperoxidase. Theadministrationof5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-4-thyoxo-thiazolidine-2-onand 2-[(4-chlor-phenyl-carbamoyl)-methyl]-3-(3,5-di-tert-butyl-4-hydroxyphenyl)-acrylicaciddidn’tdemonstrateanulcerogenicactioninsmallintestine, thatwasprobablycausedbythereleaseofH2S from these compounds.

References

Lim,Y. J., & Yang, Ch.-H. (2012). Non-SteroidalAnti-InflammatoryDrug-InducedEnteropathy. Clin.Endosc, 45 (2), 138–144.

Wallace, J.L., Caliendo, G., Santagada, V., & Cirino G. (2010). Markedlyreducedt oxicityof a hydrogensulphide-releasing derivative ofnaproxen. British Journal ofpharmacology, 159, 1236–1246.

Wallace, J.L., Dicay, M., McKnigh, W., & Martin, G.M. (2007). Hydrogensulfideenhancesulcerhealinginrats.The FASEB Journal, 21, 4070–4076.

Fomenko, I., Bondarchuk, T., & Emelyanenko, V. (2015). Changes of nitric oxide system and lipid peroxidation parameters in the digestive system of rats under conditions of acute stress, and use of nonsteroidal anti-inflammatory drugs. Current Issues in Pharmacy and Medical Sciences, 61(1), 37–41.

Chan, M. V., & Wallace, J. L. (2013). Hydrogensulfide-based the rapeutics and gastrointes tinaldiseases: translatin gphysiology totreatments. Am. Physiol.Gastrointest.LiverPhysiol, 305, 467–473.

Fomenko, I., Bondarchuk, Т., & Sklyarov, А. (2010). Dual acting COX/LOX nonsteroidal anti-inflammatory drugs versus traditional COX-2 inhibitors. Annales Universitatis Mariae Curie-Sklodowska, 3. 197–202.

Bertolini, A., Ottani, A., & Sandrini, M. (2002). Selective COX-2 inhibitors and dual acting antiinflammatorydrugs: criticalremarks. Curr.Med.Chem. 9 (10), 1033–1043.

Leone, S., & Ottani, A. (2007). Bertolini Dual acting anti-inflammatory drugs. Curr. Top. Med. Chem. 7( 3), 65–75.

Kiselyk, I.O., Lutsyk, M.D., & Shevchenko, L.Iu. (2001). Osoblyvosti vyznachennia nitrativ ta nitrytiv v peryferychnii krovi u khvorykh na virusni hepatyty ta pry syndromi zhovtianytsi inshoi etiolohii. Lab.Diahnostyka, 3, 43–45.

Green, L.C., & David A.W. (1982). Analysis of nitrate, nitrite and (1515) nitrate in biological fluids. Anal. Biochem, 126, 131–138.

Ravaeva, M.Iu. (2012). Poloksydaazota v realyzatsy y mykrovaskuliarnыkh эffektovny zkoyntensyv nohomy llymetrovoho yzluchenyia. Uchenыe zapysky Tavrycheskohonats.un-ta ym. V. Y. Vernadskoho. Seryia. Byolohyia, khymyia, 64 (3), 165–170.

Geyer, J.W. Dabich, & D.Rapid (1971). Method for determination of arginase activity in tissue homogenates. Anal. Biochem, 39 (2), 412–417.

Wilinski, B., Wilinski, J., & Somogyi E. (2010). Digoxin increases hydrogen sulfide concentration in brain, heart and kidney tissues in mice. Pharmacol. Rep, 113, 14–26.

Tymurbulatov, M.A., & Seleznev, E.Y. (1981). Metod povыshenyia svobodnoradykalnoho okyslenyia lypydsoderzhashch ykhkomponentov krovy y eho dyahnosty cheskoeznachenye. Lab.delo, 4, 209–211.

Bradley, P. P., Christensen, R. D., & Rothstein, G. (1982). Cellularan dextracel lularmyeloperoxidaseinpyogenicinflammation. Blood, 618–622.

Zhu, H., Li, Y. R. (2012). Oxidative stress and redoxs ignaling mechanism sofinflamm atorybowel disease. Experimental Biologyand Medicine, 237 (5), 474 – 480.

ZaichkoN.V. Hydrogensulfide: metabolism, biological and medical role /N.V. Zaichko, A.V. Melnik, M.M. Yoltukhivsky // Ukr. Biochem. J. – 2014. – 86, № 5. – P. 1–25.

Published
2016-11-21
How to Cite
Sklyarova, Y. O., Denysenko, N. V., Ilkiv, I. I., & Fomenko, I. S. (2016). Roleofgasotransmitters: nitrogen oxide and hydrogen sulfide in smool intestine of rats under cyclooxygenase and lipoxygenase inhibition. Medical and Clinical Chemistry, (3), 54-58. https://doi.org/10.11603/mcch.2410-681X.2016.v0.i3.6945
Section
ORIGINAL INVESTIGATIONS