CHANGES OF ANTIOXIDANT SYSTEM AND LIPID PEROXIDATION IN HEART CHAMBERS IN CONDITIONS OF POSTRESECTION PORTAL HYPERTENSION
DOI:
https://doi.org/10.11603/mcch.2410-681X.2020.i4.11731Keywords:
postresection portal hypertension, chambers of the heart, lipoperoxidation, antioxidant systemAbstract
Introduction. Postresection portal hypertension leads to hemodynamic changes and structural rearrangement of vessels and organs of the portal hepatic vein, as well as remodeling of heart structures, which are insufficiently studied.
The aim of the study – to learn the features of changes of antioxidant system, peroxidation of lipids, structures of chambers of heart in the conditions of postresection portal hypertension.
Research Methods. Biochemical and morphological methods were used to study changes in the antioxidant system, lipid peroxidation, and the structures of the heart chambers of 40 laboratory adult white male rats, which were divided into 2 groups. Group 1 consisted of 20 intact animals (control), group 2 – 20 rats after removal of the right and left lateral lobes of the liver (58.1 %). Euthanasia of rats was carried out by bloodletting under conditions of thiopental anesthesia in 1 month after the beginning of experiment. Stromal-parenchymal ratios, relative volumes of damaged cardiomyocytes and endothelial cells were determined histostoreometrically on micronutrients. Quantitative values ?were processed statistically.
were processed statistically.
Results and Dscussion. It was found that the removal of the left and right lobes of the liver in white rats leads to postresection portal hypertension, marked changes in antioxidant system, lipid peroxidation and myocardial structures. The most pronounced morphological changes were found in the left ventricle and left atrium.
Conclusions. Removal of the left and right lateral lobes of the liver in white rats leads to postresection portal hypertension, deterioration of antioxidant defenses of the body, morphological changes in the structures chambers of the heart, increasing concentrations of lipoperoxidation products that correlate with stromal-parenchymal relationships, relative volumes damaged cardiomyolcytes and endotheliocytes. Morphological changes in the left ventricle and left atrium are dominated..
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