CHANGES OF ANTIOXIDANT SYSTEM AND LIPID PEROXIDATION IN HEART CHAMBERS IN CONDITIONS OF POSTRESECTION PORTAL HYPERTENSION
DOI:
https://doi.org/10.11603/mcch.2410-681X.2020.i4.11731Keywords:
postresection portal hypertension, chambers of the heart, lipoperoxidation, antioxidant systemAbstract
Introduction. Postresection portal hypertension leads to hemodynamic changes and structural rearrangement of vessels and organs of the portal hepatic vein, as well as remodeling of heart structures, which are insufficiently studied.
The aim of the study – to learn the features of changes of antioxidant system, peroxidation of lipids, structures of chambers of heart in the conditions of postresection portal hypertension.
Research Methods. Biochemical and morphological methods were used to study changes in the antioxidant system, lipid peroxidation, and the structures of the heart chambers of 40 laboratory adult white male rats, which were divided into 2 groups. Group 1 consisted of 20 intact animals (control), group 2 – 20 rats after removal of the right and left lateral lobes of the liver (58.1 %). Euthanasia of rats was carried out by bloodletting under conditions of thiopental anesthesia in 1 month after the beginning of experiment. Stromal-parenchymal ratios, relative volumes of damaged cardiomyocytes and endothelial cells were determined histostoreometrically on micronutrients. Quantitative values ?were processed statistically.
were processed statistically.
Results and Dscussion. It was found that the removal of the left and right lobes of the liver in white rats leads to postresection portal hypertension, marked changes in antioxidant system, lipid peroxidation and myocardial structures. The most pronounced morphological changes were found in the left ventricle and left atrium.
Conclusions. Removal of the left and right lateral lobes of the liver in white rats leads to postresection portal hypertension, deterioration of antioxidant defenses of the body, morphological changes in the structures chambers of the heart, increasing concentrations of lipoperoxidation products that correlate with stromal-parenchymal relationships, relative volumes damaged cardiomyolcytes and endotheliocytes. Morphological changes in the left ventricle and left atrium are dominated..
References
Volchenko, I.V., Lykhman, V.M., Skoryy, D.I., & Shevchenko, A.M. (2016). Osoblyvosti vykonannia obshchyrnykh rezektsii pechinky z urakhuvanniam profilaktyky pisliaoperatsiinykh uskladnen [Peculiarities of performing extensive liver resections taking into account the prevention of postoperative complications]. Kharkivska khirurhichna shkola – Kharkiv Surgical School, 3 (78), 35-39 [in Ukrainian].
Dronov, O.I., Zemskov, S.V., Bakunets, Y.P., & Bakunets, P.P. (2016). Khirurgicheskoye lecheniye ochagovogo porazheniya pecheni analiz rezultatov i perspektivy [Surgical treatment of focal liver disease: analysis of results and prospects]. Klinicheskaya khirurgiya – Clinical Surgery, 1, 28-31 [in Russian].
Dzyhal, O.F. (2017). Formuvannia polisyndromnoi nedostatnosti khvorykh na tsyroz pechinky z portalnoiu hipertenziieiu [Formation of polysyndromic insufficiency of patients with liver cirrhosis with portal hypertension]. Visnyk naukovykh doslidzhen – Bulletin of Scientific Research, 2, 88-92 [in Ukrainian].
Garbuzenko, D.V. (2014). Morfofunktsionalnaya perestroyka pechenochnogo sosudistogo rusla v patogeneze portalnoy gipertenzii pri tsirroze pecheni [Morphofunctional rearrangement of the hepatic vasculature in the pathogenesis of portal hypertension in liver cirrhosis]. Ter. Arkh. – Ter.Arch., 86 (2), 90-95 [in Russian].
Hnatiuk, M.S., Tatarchuk, L.V., & Jasinovskyy, O.B. (2016). Morfometrychna otsinka osoblyvostei remodeliuvannia struktur dvanadtsiatypaloi kyshky pry resektsii riznykh obiemiv pechinky [Morphometric evaluation of the features of remodeling of duodenal structures during resection of different volumes of the liver]. Naukovyi visnyk Uzhhorodskoho universytetu. Seriia “Medytsyna” – Scientific Herald of Uzhhorod University. Series "Medicine", 1 (49), 3-5 [in Ukrainian].
Flekey, N.V. (2015). Stan antyoksydantnoi systemy v bilykh shchuriv pry vvedenni kadmiiu na tli spozhyvannia pytnoi vody z riznymy kontsentratsiiamy ioniv natriiu [The state of the antioxidant system in white rats with the introduction of cadmium on the background of drinking water consumption with different concentrations of sodium ions]. Medychna ta klinichna khimiia – Medical and Clinical Chemistry, 2 (63), 84-86 [in Ukrainian].
Goralsky, L.P., Khomich, V.T., & Kononsky, O.I. (2011). Osnovy histolohichnoi tekhniky i morfofunktsionalni metody doslidzhen u normi i pry patolohii [Fundamentals of histological technique and morphofunctional research methods in normal and in pathology]. Zhytomyr: Polissia [in Ukrainian].
Avtadnilov, G.G. (2002). Osnovy kolichestvennoy patologicheskoy anatomii [Basis of quantitative pathological anatomy]. Moscow: Meditsyna [in Russian].
Proskurnina, E.V., Sherimova, A.E., Polimova, P.M., & Sozarukova, M.M. (2016). Novi luminestsentni metody otsenky okyslitelnogo stresa u bolnykh s systemnymy vaskulitamy [New luminescent methods for assessing oxidative stress in patients with systemic vasculitis]. Tekhnologii zhyvykh system – Technologies of Living Systems, 13 (8), 26-36 [in Russian].
Grzhibovskiy, A.I., Ivanov, O.V., & Gorbatova, M.A. (2016). Sravneniye kolichestvennykh dannykh dvukh parnykh vyborok s vnedreniyem programmnogo obespecheniya Statistica i SPSS: parametricheskiye i neparametricheskiye kriterii [Comparison of quantitative data of two paired samples using Statistica and SPSS software: parametric and nonparametric criteria]. Nauka i zdravookhraneniye – Science and Health, 3, 5-25 [in Russian].
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Medical and Clinical Chemistry
This work is licensed under a Creative Commons Attribution 4.0 International License.