STRUCTURAL CHANGES OF THE STOMACH MUCOUS MEMBRANE IN CASE OF CHRONIC GASTRITIS WITH LAMBLIOSIS AND H. PYLORI INFECTION IN CHILDREN
DOI:
https://doi.org/10.11603/1811-2471.2018.v0.i2.8905Keywords:
children, Giardia intestinalis, H. Pylori, chronic gastritis, biopsy.Abstract
In recent years, researchers' attention to the effect of parasitoses on the course of diseases of the digestive system in children has grown, because intestinal parasites are one of the most common pathogens of the gastrointestinal tract.
The aim – a comparative analysis of structural changes in the gastric mucosa in children with chronic gastritis, depending on the combination of H. pylori infection and Giardia intestinalis invasion.
Material and Methods. Clinical-laboratory and instrumental examination of children with chronic gastritis aged 7 to 17 years old was conducted, morphological and morphometric features of the stomach mucous membrane after the biopsy were investigated.
Results. The minimal pathohistological and morphometric changes in the stomach mucous membrane are observed in children with chronic gastritis with Giardia intestinalis monoinvasion. While the combination of lambliosis and H. pylori infection in chronic gastritis causes dystrophic-necrotic changes in the epithelium, regeneration disturbances, intestinal metaplasia and circulatory disorders. This is confirmed by the maximum decrease of the nuclear-cytoplasmic ratio (0.0584±0.0047), an increase of the infiltrate cell density by 9.84 % and a decrease of the relative volume of the capillaries and the capillary-epitheliocytic ratio compared with the Giardia intestinalis monoinvasion.
Conclusions. The maximum pathohistological and morphometric changes occurred in the research group of patients with chronic gastritis associated with H. pylori in combination with lambliosis.
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