PECULIARITIES OF PERIODONTAL CARBOHYDRATE-PROTEIN OF CONNECTIVE TISSUE COMPONENTS METABOLISM AND ITS CYTOKINE REGULATION IN PATIENTS WITH DUODENAL ULCER DEPENDING ON THE TYPE OF FIXED DENTURES
DOI:
https://doi.org/10.11603/1811-2471.2017.v0.i1.7523Keywords:
duodenal ulcer, fixed metal dentures, connective tissue, cytokines.Abstract
The aim of the work – to determine the influence of fixed metal, metal-ceramic and ceramic dentures on the state of protein and carbohydrate components of periodontal connective tissue and their cytokine regulation in patients with duodenum ulcer (DPU).
Materials and Methods. 147 patients with duodenal ulcer were examined using modern clinical, biochemical and immunoenzyme methods, including 43 persons with edentulous spaces without dentures (group 1), 35 people with fixed metal dentures (group 2), 42 patients with ulcer with fixed metal-ceramic dentures ( 3 group), 27 patients with fixed ceramic dentures (group 4).
Results. In patients with DU without denture a significant changes in metabolism of the periodontal extracellular matrix (ECM) components were established, likely reducing the intensity of the synthesis of collagen, glycosaminoglycans, glycoproteins and fibronectin on the background of increasing the intensity of collagenolysis and fukoglycoproteins degradation. The presence of metal fixed dentures leads to a substantial deepening of imbalances due to increased activity of collagenase and elastase of ECM, overproduction of proinflammatory cytokines (TNF-α, IL-1) and failure of growth factors (TGF-β1) with anabolic action in the blood, which have a strong correlation with the intensity of reactions ana- and catabolism of collagen, elastin, blood levels of glycosaminoglycans, fukoglycoproteins, fibronectin content. Conclusions. The presence of metal fixed dentures in patients with DPU reduces collagen synthesis and increases collagenolytic activity of plasma due to increased activity of collagenase and elastase of ECM, accompanied by hyperproduction of proinflammatory cytokines (TNF-α, IL-1) against the deficiency of blood growth factors (TGF-β1) content, which were significantly higher in comparison with patients with DPU without dentures and in patients with fixed ceramic dentures.
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