THROMBOPHILIA, COMPLICATED BY RECURRENT PULMONARY THROMBOEMBOLISM – CLINICAL CASE WITH ANALYSIS OF MODERN DIAGNOSTIC AND TREATMENT ALGORITHMS
DOI:
https://doi.org/10.11603/1811-2471.2018.v0.i4.9745Keywords:
pulmonary thromboembolism, thrombophilia, diagnostics, treatmentAbstract
Venous thrombosis or embolism (VTE) is one of the most severe life-threatening complications.
The aim of the study – to analyze modern approaches to diagnosis and treatment of patients with thrombophilia complicated by recurrent pulmonary thromboembolism on the basis of own clinical case.
Results. For evaluation of VTE risk the Padua scale is recommended, especially in young patients. A compulsory screening to confirm or rule out the congenital or acquired thrombophilia that determines the program for the prevention of recurrent VTE should be performed. In patients with diagnosed thrombophilia it is necessary to use a personified choice of anticoagulants. Indications for the use of direct or indirect anticoagulants are determined by specific forms of thrombophilia. This diagnostic algorithm allows prescribing adequate preventive anticoagulant therapy in such patients, which was confirmed in our clinical case.
Conclusions. The high incidence of VTE, lack of knowledge among practitioners regarding the diagnosis of the disease, identification of its causes and clinical forms, and the ambiguity of results of various programs of treatment and prevention of VTE, substantiate the need for additional multicenter clinical trials and a broader discussion of this problem among medical society.
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