COMPARATIVE CHARACTERISTICS OF THE RESULTS OF USING ADEMETIONINE AND ITS REMOTE EFFECTS ON CELLULAR IMMUNITY PARAMETERS IN HIGHLY SKILLED ATHLETES AND IN PATIENTS WITH CHRONIC HEPATITIS C

Abstract

Athletes of high professional skill at the height of maximum physical activity observed statistically significant changes in cellular immunity, which in many respects resemble similar changes in chronic hepatitis C. Admission of ademetionine by athletes during the recovery period led to normalization of cellular immunity indicators, which remained stable in the long-term period.

The aim of the study – to conduct a comparative analysis of lymphocyte subpopulations in athletes of high professional skills during the period of maximum physical exertion and in patients with chronic hepatitis and the effect of ademetionin hepatoprotector on the cellular immunity indices in both groups.

Materials and Methods. 38 practically healthy individuals, 34 athletes-biathlete of high professional skills at the height of maximum physical exertion and 40 patients with chronic hepatitis C were examined. The cellular immunity parameters were evaluated: T-lymphocytes (CD3+, CD19-), T-helper / T-inducers (CD4+, CD8-), T-suppressors / T-cytotoxic cells (CD4-, CD8+), immunoregulatory index, cytotoxic cells (CD3+, CD56+), NK cells (CD3-, CD56+), B-lymphocytes (CD3-, CD19+), monocytes (CD14), common leukocyte antigen (OLA, CD45). Diagnostic methods: flow cytofluorimetry.

Results and Discussion. The indicators of cellular immunity, which vary in athletes of high professional skill during the period of maximum physical exertion, are determined, and the positive effect of ademetionine on the normalization of athletes’ immune status during its administration and in the long-term period is shown. In chronic hepatitis C, normalization of cellular immunity parameters was also observed while taking ademetionine, but it was short and disappeared after the withdrawal of the hepatoprotector.

Conclusons. Ademethionine has a positive effect on cellular immunity, both in athletes of high professional skill during the period of maximum physical exertion and in patients with chronic hepatitis C, but in the latter normalization was short-lived.