AGE PECULIARITIES OF ACTIVATION OF LIPID PEROXIDATION PROCESSES IN THE KIDNEY IN EXPERIMENTAL CRANIOSKELETAL INJURY CONDITIONS

Abstract

Introduction. The problem of polytrauma is relevant in Ukraine and in the world. Every year the frequency of high-kinetic lesions increases, which are accompanied by severe multiple and combined injuries, which is the main cause of death in persons of working age. According to the WHO, injuries, as the main cause of death, will soon affect people of all age groups. Therefore, from now on the actual task of modern medicine is to deepen knowledge about the pathogenesis of polytrauma in the age aspect.

The aim – to find out the content of TBA-active LPO products in the kidney in the dynamics of early manifestations of cranioskeletal trauma in individuals of different age groups.

Material and Methods. Experiments were performed on nonlinear white male rats of three age groups (100–120 days, 6–8 months and 19–23 months). In experimental groups, a cranioskeletal trauma, simulated for animals of different age groups, was modeled under thiopental-sodium anesthesia. The control group consisted of 7 animals in each age group, which were only injected into thiopental-sodium anesthesia. After 1, 3 and 7 days after injuries in the kidneys of experimental animals, the activity of lipid peroxidation processes on the content of TBA-active products was evaluated.

Results. It was found that control of the intensity of lipid peroxidation processes in the kidney prevailed in young rats. After injuries in the acute period (1 day) in young animals, the content of TBA-active products did not change, whereas in adults and old animals, the content of TBA-active products did not change significantly. After 3 days in animals of all age groups, the level of LPO increased, but clearly dominated by older animals, then adults and young ones. However, after 7 days, the content of the TBA-active product in the kidney in young rats increased sharply, while in the older ones it decreased. The obtained results suggest that the intensification of LPO in the kidney is an important factor in the pathogenesis of its secondary lesion in the languages ​​of the acute period and the period of early manifestations of traumatic illness,

Conclusion. Normally, the intensity of lipid peroxidation processes in the kidney is dominated by young rats. After injuries in the acute period (1 day) in young animals, the content of TBA-active products of the LPO practically does not change, while in adults and old animals the growth is significant. By 3 days, the index is increasing in all age groups, but clearly prevails in older animals, then adults and young people. After 7 days, the content of TBA-active LPO in the kidney in young and adult rats continues to increase with a clear prevalence in the younger age group, while in the older ones it decreases.