GENDER ISSUES OF CLINICAL COURSE AND TREATMENT OF ACUTE CORONARY SYNDROME
DOI:
https://doi.org/10.11603/1811-2471.2018.v0.i2.8932Keywords:
acute coronary syndrome, myocardial infarction without obstruction of coronary arteries, percutaneous coronary intervention, fibrinolysis.Abstract
Cardiovascular diseases are among leading causes of mortality in both men and women. However, acute coronary syndrome in women often remains undiagnosed and untreated due to lack of awareness of this problem by women, the presence of atypical symptoms, delay in time with the correct diagnosis and lesser use of invasive treatments.
In this article the main features of the clinical course of acute coronary syndrome in women, in particular myocardial infarction without obstruction of the coronary arteries, are highlighted. At the same time, the general principles of diagnostics and management for both sexes are emphasized, regardless of the presence of certain gender differences, as well as the list, indications for use and doses of fibrinolytic, anticoagulant and antiplatelet agents from the standpoint of evidence-based medicine.
References
Ibanez, B., James, S., & Agewall, S. (2017). 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. European Heart Journal, 39, 1-66.
Chieffo, A., Buchanan, G.L., & Mauri, F. (2012). ACS and STEMI treatment: gender-related issues. Euro Intervention, 27-35. doi: 10.4244/EIJV8SPA6.
Kawamoto, K.R., Davis, M.B., & Duvernoy, C.S. (2016). Acute coronary syndromes: differences in men and women. Curr. Atheroscler. Rep., 18 (12), 73.
Khan, N.A., Daskalopoulou, S.S., & Karp, I. GENESIS PRAXY Team (2013). Sex differences in acute coronary syndrome symptom presentation in young patients. JAMA Intern. Med., 173 (20), 1863-1871. doi: 10.1001/jamainternmed.2013.10149.
Khan, N.A., Daskalopoulou, S.S., & Karp, I. GENESIS PRAXY Team (2017). Sex differences in prodromal symptoms in acute coronary syndrome in patients aged 55 years or younger. Heart, 103 (11), 863-869. doi: 10.1136/heartjnl-2016-309945. Epub 2016 Dec 13.
Shved, M.I., & Lypovetska, S.Y. (2018). Hostryi koronarnyi syndrom: henderni vidminnosti kriz pryzmu novykh rekomendatsii Evropeiskoho kardiolohichnoho tovarystva [Acute coronary syndrome: gender differences in highlight of new guidelines of European society of cardiology 2017]. Zbirnyk nauk. prats Vseukr. Naukovo-prakt. Konferentsii “Zhinoche zdorovia: implementatsiia suchasnykh protokoliv v klinichnu praktyku” – Collection of Scientific Works Of All-Ukrainian Scientific and Practical Conference “Women’s Health: Implementation of Modern Protocols in Clinical Praсtice”. Ternopil [in Ukrainian].