STUDY OF DYNAMICS OF CD4+ CD25+, CD4+ HLA-DR4+ AND CD4+CD95+ LEVELS OF SPERM LYMPHOCYTES IN INFERTILE MEN WITH CHRONIC INFLAMMATION OF UROGENITAL TRACT WITH INFLUENCE OF NUCLEUS

Abstract

Introduction. In the practice of family doctors cases of male appetite with a violation of the fertilizing function have become more frequent. A careful collection of history suggests that reducing fertility in men is accompanied by a latent and persistent flow of urogenital infections, which makes it difficult to timely diagnose them.

The aim – to investigate the activation markers of sperm lymphocytes in males with asymptomatic forms of chronic infection of the urogenital tract, depending on the fertility and the effect of the nucleus on their level.

Material and Methods. The study was conducted on sperm of 60 men suffering from malosymptomatic forms of chronic inflammation of the urogenital tract (CIUT); And the group I consisted of 32 patients, in whom complications were diagnosed – infertility, group ІІ included 28 fertile patients.

Conclusions. 1. Study of the markers of activation of lymphocytes of sperm in men suffering from low-asymptomatic forms of chronic infection of the urogenital tract, indicates a diverse increase in their number depending on fertility.

2. Diagnostically important is the determination of the ratio of CD25+/CD95+ to predict the development of infertility. The increase of this index indicates the violation of the processes of apoptosis of pathological forms of the generative cells, which leads to their accumulation in the semen.

3. Immunocorrection therapy using the nucleus leads to the normalization of the ratio of CD25+/CD95+, to the reduction of pathological forms of sperm and, ultimately, to increase the fertility potential.