CHANGES OF ELECTROCARDIOGRAM INDICATORS WITH ADRENALIN-CALCIUM MODEL OF HEART DAMAGE OF MALE RATS AND USING THE CORECTION OF QUERCETIN
DOI:
https://doi.org/10.11603/1811-2471.2018.v0.i1.8633Keywords:
heart, adrenalin-calcium defeat, quercetin, electrocardiogram, rat.Abstract
Introduction. Actual task of the present day is to investigate cardioprotective medication in the development of cardiovascular pathology, one of which is quercetin.
The aim of the study was to determine changes in the parameters of electrocardiogram (ECG) in male rats with adrenalin-calcium myocardial injury (ACM) and to correct the pathological process by quercetin.
Material and Methods. Experiments were performed on male rats of the Wistar line (control, 1 hour, 2 hours, 24 hours, 3 days, 7 days, 14 days, 21 days, 28 days ACM, quercetin (Q), 7 days ACM + Q, 14 days ACM + Q, 21 days ACM + Q, 28 days ACM + Q). The apparatus "Cardiolab" was used for registration and analysis of ECG.
Results. In the group of 28 days of AСM the mortality rate was 16.67 %, in the group 28 days AСM + Q – 8.33 %. Throughout the experiment, animals have bradycardia. After 2 hours, the PQ interval is lengthened, the deviation of the ST segment relative to the isoline becomes significant, the amplitude of the wave R was reduced. After 24 hours, high sharpened wave T appeared. After 3 days, prolongation of the intervals PQ, QTc, low amplitude of P wave. After 7 days – elongation of the interval QTc, increase in the amplitude of the waves R, T, deviation of the segment ST. After 14 days, the lengths of the intervals PQ, QTc are prolonged, remains a significant deviation of the ST segment relative to the isolation. After 21 days, elongated of intervals PQ, QTc, decreases the amplitude of the T wave.
Quercetin has tread effect 7 days after the injection.
Conclusions. Injection of adrenaline hydrotartrate and calcium gluconate to rats causes changes in ECG in a wave- like manner. Quercetin has a tread effect on the development of adrenalin-calcium heart disease in rats.
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