LARGE INTESTINE DYSBIOSIS IN PATIENTS WITH COMBINATION OF DIABETES MELLITUS TYPE 2 AND CHRONIC NONCALCULOUS CHOLECISTITIS
DOI:
https://doi.org/10.11603/1811-2471.2018.v0.i2.8483Keywords:
diabetes mellitus type 2, chronic noncalculous cholecystitis, intestinal dysbiosis.Abstract
The aim of the study – to learn the changes in the quantitative and qualitative composition of the large intestine microflora in patients with diabetes mellitus (DM) type 2 and chronic noncalculous cholecystitis (CAC).
Material and Methods. 52 patients who were treated in the Gastroenterological and Endocrinology Departments of the Transcarpathian Regional Hospital named after A. Novak in Uzhhorod were involved in the study. DM type 2 diagnosis was based on the recommendations of the International Diabetes Federation (IDF, 2005). The exacerbation of the CNC diagnosis was based in accordance with the clinical protocol of the Ministry of Health of Ukraine and local protocols. The feces for dysbiosis were examined in patients with DM type 2 and CNC. The degree of intestinal dysbiosis was evaluated according to the classification of Kuvayeva I. B., Ladodo K. S. (1991).
Results. The main clinical manifestation of the exacerbation of CNC in examined patients with DM type 2 was pain and dyspepsia syndromes. The nagging pain was localized mainly in the right hypochondria region with a characteristic irradiation to the right shoulder and right shoulder blade. The manifestations of biliary dyspepsia and intestinal dyspepsia (flatulence, alternating diarrhea and constipation) were examined in patients with DM type 2. Changes in the quantitative and qualitative composition of the large intestine microflora were observed in all examined patients with DM type 2 and CNC according to the results of microbiological study. At the same time, dysbiosis, mainly III and II degrees were found in patients with combination of DM type 2 and CNC, namely – III degree dysbiosis in 53.9 % of patients, II degree – in 36.5 % of patients and only 9.6 % of patients had I degree dysbiosis. It has been established that dyspeptic syndrome is more pronounced and more commonly found in patients with combination of CAC and DM type 2 with III degree dysbiosis.
Conclusions. 1. The large intestine dysbiosis, mainly III and II degrees (in 53.9 % and 36.5 % of patients respectively) was observed in patients with DM type 2 and CNC.2. The connection between the severity of manifestations of dyspeptic syndrome and dysbiosis, mainly of the III degree were observed in patients with DM II type and CNC.
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