STRATIFICATION OF MODIFIED RISK FACTORS OF ATHEROSCLEROSIS IN PATIENTS WITH CHRONIC PANCREATITIS
DOI:
https://doi.org/10.11603/1811-2471.2017.v0.i4.8357Keywords:
atherosclerosis, chronic pancreatitis, modified risk factors.Abstract
The article describes and analyzes the influence of the main risk factors of atherosclerosis in patients with chronic pancreatitis.
The aim - to identify and research risk factors of atherosclerosis in patients with combination of chronic pancreatitis and dyslipidemia.
Materials and Methods. We conducted mixed triglyceride 13C breath test (13C-MTBT) and amylase 13C-breath test (13C-ABT) for detection of exocrine pancreatic insufficiency (EPI). Atherosclerotic changes were diagnosed by measuring the thickness of the intima-media layer in the carotid artery and changes in the lipid profile of the blood (by determining the total blood plasma cholesterol (CF), triglycerides (TG), high density lipoprotein cholesterol (HDL), low density lipoprotein (LDL) and atherogenicity).
Results. The exocrine pancreatic insufficiency was observed in all patients by using the triglyceride respiratory test. The violation of the lipid profile, namely: hypercholesterolemia, hypertriglyceridemia, and increase in atherogenicity was found in all patients. It has been shown that obesity or insufficient body weight cannot serve as a criterion for determining the degree of exocrine pancreatic insufficiency or the severity of atherosclerotic disorders in patients with combination of chronic pancreatitis and atherosclerosis. It is proved that triglyceride respiratory test is a method of choice for early diagnosis of exocrine pancreatic insufficiency. The significant influence of the modified risk factors of atherosclerosis on the course of chronic pancreatitis was revealed by using the testing methods, questionnaires and surveys.
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