STRUCTURAL AND FUNCTIONAL REACTION OF PULMONARY TISSUE AND BLOOD VESSELS OF PULMONARY CIRCULATION OF LABORATORY RATS AT THE EARLY STAGES OF MODELING OF ACUTE PERITONITIS
DOI:
https://doi.org/10.11603/1811-2471.2017.v1.i3.7745Keywords:
acute peritonitis, pulmonary parenchyma, vessels of pulmonary circulation, alveoli, interalveolar septa, endothelium.Abstract
The aim of our research was the experimental study of morphological and functional changes in lung tissue in the development of acute peritonitis.
Material and methods of investigation: morphometric (measurement of interalveolar septa thickness, diameter of alveoli), histological for studying of lung tissue structure on the light-optical level, statistical. The experiment was performed on 40 white male rats: 10 animals were as an intact control group, 30 animals were modeled with acute peritonitis.
Results of the research. Despite the significant progress of clinical medicine, peritonitis and its associated complications are the one of the important problems of surgical practice. Polyorgan failure (as a consequence of acute peritonitis) is an impotent cause of complication of the disease and lethality. And the lungs are the one of the first target of this disease. In the study, already during the development of the toxic stage of acute peritonitis, the morphological signs of the reactions of blood vessels in both the lungs and bronchial were observed light-optically. The desquamated epithelial cells were observe in the lumens of bronchioles. Activation of the secretory function of goblet cells of bronchial mucosa, local expansion of alveoli, thickening of most alveolar septa became a reaction to the course of the pathological process. The appearance of spasmodic bronchioles was characteristic at this time.
Conclusions. Experimental acute peritonitis in white male rats caused a reaction in the bronchi epithelium, in alveoli and in the vascular system of lung. The acute peritonitis initiates endotoxicosis and development of dystrophic processes and disruption of normal tissue-vascular interactions. In the early stage of acute peritonitis, the course of compensatory-adaptive reactions occurred in parallel with the development of signs of destruction: an increase in the secretory activity of goblet cells, increasing clearance of some alveoli, thickening of interalveolar septa, edema of structural elements of the walls of the blood vessels.
References
Banul B.Yu., Makar B.H. (2014). Funktsionalʹna ta strukturni zminy v orhanakh dykhalʹnoyi systemy pid vplyvom riznykh chynnykiv [Functional and structural changes in the respiratory system under the influence of various factors]. Klinichna anatomiya ta operatyvna khirurhiya – Clinical Anatomy and Operative Surgery, Vols 13, 2, 94–98 [in Ukrainian].
Bilyk I.I. (2013). Hostryy perytonit yak uskladnennya hostroho apendytsytu [Acute peritonitis as a complication of acute appendicitis]. Klinichna ta eksperymentalʹna patolohiya – Clinical and Experimental Pathology, Vols 12, 1 (43), 187–189. Retrieved from https://www.bsmu.edu.ua/files/KEP/%CA%C5P-2013-01/187.pdf [in Ukrainian].
Voytiv Ya.Yu. (2010) Profilaktyka ta likuvannya kyshkovoyi nedostatnosti pry perytoniti [Prevention and treatment of intestinal failure at peritonitis]. Extended abstract of candidate’s thesis. Lviv: National Medical University named Danylo Galician [in Ukrainian].
Gerasymyuk I.Ye., Chepesuk V.O., Hantimurov A.V., Gerasymyuk L.O. (2009). Osoblyvosti dynamiky morfofunktsionalʹnykh zmin u koronarnomu rusli ta sudynakh maloho kola krovoobihu pry perebihu hostroho rozlytoho perytonitu [The features of dynamics of morphological changes in the coronary vessels and pulmonary circulation during the course of acute diffuse peritonitis]. Zdobutky klinichnoyi i eksperymentalʹnoyi medytsyny – Achievements of clinical experimental Medicine, 2, 35-38 [in Ukrainian].
Muntyan S.O., Kryshen' V.P., Barannyk S.I., Liashchenko P.V., Likholetov Ye.O. (2014). Dynamika pokaznykiv CD8-limfotsytiv pry prolonhovanomu intraabdominalʹnomu sorbtsiyno-transmembrannomu dializi u khvorykh z rozpovsyudzhenym perytonitom [Dynamics of CD8-lymphocyte counts with prolonged intra-abdominal sorption-transmembrane dialysis in patients with advanced peritonitis]. Aktualʹni problemy suchasnoyi medytsyny – Actual problems of modern medicine, Vols 14, 2 (46), 83-85 [in Ukrainian].
Palchyk S.M., Voronzhev I.O., Kramnyy I.O. (2016). Morfoklinichni ta promenevi aspekty diahnostyky bronkholehenevykh zakhvoryuvanʹ ta yikh uskladnenʹ v ditey z dysplaziyeyu spoluchnoyi tkanyny [Morpho-clinical and radiation aspects of diagnosis of bronchopulmonary diseases and their complications in children with connective tissue dysplasia]. Perinatologiya i pediatriya – Perinatology and Pediatrics, 2 (66), 133-139 [in Ukrainian].
Pol'ovyy V.P., Sydorchuk R.I., Palyanytsya A.S., Kulachek Ya.V., Nurdipov Kh.N., Hrodetskyy V.K. (2014). Klinichne doslidzhennya chutlyvosti zbudnykiv hostroho perytonitu do antymikrobnykh preparativ [Clinical study of sensitivity of pathogens of acute peritonitis to antimicrobial drugs]. Klinichna anatomiya ta operatyvna khirurhiya – Clinical Anatomy and Operative Surgery, Vols 13, 3, 32-34 [in Ukrainian].
Pronyna O.M., Koptev M.M., Danylchenko S.I., Polovyk O.Yu. (2011). Premorbidni zminy lehenevoyi tkanyny vnaslidok hostroyi stresovoyi reaktsiyi v eksperymenti [Premorbid changes in pulmonary tissue due to acute stress reaction in the experiment]. Visnyk problem biolohiyi i medytsyny – Bulletin of the problems of biology and medicineб, Is. 3, Vols 2 (88), 154-156 [in Ukrainian].
Strukov A.I., Petrova V.I., Paukova V.S. (Eds.). (1987). Ostryy razlitoy peritonit [Acute diffuse peritonitis]. Moscow: Medicine [in Russian].
