THE CHANGES OF INDICATORS OF THE KININ-KALLIKREIN SYSTEM IN PATIENTS WITH CHRONIC PANCREATITIS WITH CONCOMITANT DIABETES MELLITUS
DOI:
https://doi.org/10.11603/1811-2471.2017.v0.i2.7711Keywords:
chronic pancreatitis, diabetes mellitus, kinin–kallikrein system.Abstract
SUMMARY. The kinin-kallikrein system plays an important role in the course of chronic pancreatitis (CP) with concomitant diabetes mellitus.
The aim of our work was to investigate the effect of diabetes mellitus on the parameters of the kinin–kallikrein system in patients with CP.
Material and Methods. The study involved 112 patients with CP that were divided into 2 groups: I group – 35 patients with CP without diabetes; II group – 77 patients with CP with concomitant diabetes.
Conclusions. A statistically significant activation of proteolytic activity, increase of the proteolytic enzyme of the kallikrein, decrease of the prekallikrein level, increase of the α1-proteinase inhibitor and α2-macroglobulin levels and decrease of the kininase-II activity in patients with CP with concomitant diabetes (p<0.05) compared to patients with only CP have been proved. This ascertains a complicating role of injury of kinin-kallikrein system in comorbidity of CP and diabetes.
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