CERTAIN CONTENT FEATURES AND TUMORNEKROTYCHNOHO METABOLIC FACTORS IN PATIENTS WITH COMORBID DISEASES

Abstract

SUMMARY. It is known that the regulation of trophic and reparative processes of tissues play a significant role metabolites of arachidonic acid and lipoperoxide derivatives, which emphasizes their role in recurrence and / or chronization inflammation and, moreover, does not exclude them much greater influence on the course of diseases in comorbidity .

The aim was to study the contents of lipoxygenase metabolites of arachidonic acid (leukotrienes (LT) B4 and C4; radio immune method), and finished lipid peroxyl compounds (diene conjugates (DC) and malonic dyaldehyde (MDA); spectrophotometric method) and serum tumornecrotic factor α (TNFα; immune enzyme method) during the treatment of 40 patients (age 37 – 49 years, 25 men and 15 women), peptic ulcer disease (UD), in 23 of which it was comorbid with chronic bronchitis; Reference rate figures were 20 healthy individuals (groups did not differ by age and gender).

It was found that comorbid patients after treatment LTV4 level compared with patients Visitor Messages (108.5±20.6 pg/ml) was increased 1.3 times (healthy – 53.2±11.4 pg/ml; p<0.001) and more than 1.4 times – LTS4 level (in patients Visitor Messages – 98.7±18.9 pg/mL; reference rate – 39.7±10.4 pg/ml, p<0.001). It is found, something increased content lipoxygenaze AK metabolites in patients with comorbid diseases was also accompanied by significant increase in the level of intermediate and final lipoperoxide compounds, while the UC level in patients with comorbid disorders higher than that of patients at the Preparatory almost around one third (6.81±0.33 mmol/l, p<0.001), and the content of MDA – more than a quarter (9.53±0.41 mmol/l, p<0.001). These metabolic changes in comorbid patients after treatment was accompanied by more than half, increased serum TNFα (51.0±2.8 pg/ml in healthy – 24.5±3.2 pg/ml, p<0.001) which was also 1.34 times higher compared with patients at the Preparatory after treatment. Found features content lipoxygenaze metabolites of arachidonic acid, and finished lipoperoxide compounds and pro-inflammatory TNFα after treatment in patients with comorbid diseases show preserving their high blood inflammatory activity that involves the development of measures to optimize the treatment and prophylaxis of the designated disease in this category of patients.