MORPHOLOGICAL CHANGES IN THE LIVER OF MATURE FEMALE WHITE RATS UNDER THE EXPERIMENTAL CHRONIC TOXIC HEPATITIS AND THEIR IMPACT ON REPRODUCTION
DOI:
https://doi.org/10.11603/1811-2471.2016.v0.i4.7080Keywords:
morphological changes of the liver, chronic toxic hepatitis, reproductive function.Abstract
The worsening demographic situation in Ukraine over the past decades continues. Therefore, the reproductive health of the nation in Ukraine is a priority of health and medical science. A significant reason for the negative demographic indicator is the high level of infertility, including endocrine genesis, is 15–25 % [1]. Impaired function of the reproductive system is an urgent problem because not only lead to loss of efficiency, but also reduce human reproduction. A significant role in causing of endocrine infertility includes not only genetically determined changes in women, but comorbidity. Women have often a combination of reproductive system dysfunction with chronic hepatitis of different genesis. This prompted us to perform experimental work for a detailed study and analysis of this problem. In the foreseeable literature we found no such experimental studies on pathological process modeling and study of the structural changes in the liver and reproductive organs in chronic hepatitis. We modeled chronic toxic hepatitis in mature female white rats. We studied the results of the clinical, histological studies, indicators of immune and hormonal status, liver function in experimental animals and their reproductive function under the experimental toxic hepatitis. The study involved 40 sexually mature females of white rats that simulated chronic toxic hepatitis (CTH). Were studied the clinical manifestations of the disease, the condition of liver function, hormonal status, morphological changes in the liver of these animals and their reproductive function.References
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