THE ACTION OF THE EXTRACT OF ECHINACEA PURPUREA AND THIOTRIAZOLINE ON DEPTH OF PITS OF PYLORIC MUCOUS MEMBRANE OF THE STOMACH OF RATS UNDER INHALATION EPICHLOROHYDRIN
DOI:
https://doi.org/10.11603/1811-2471.2016.v27.i3.6780Keywords:
stomach, mucous membrane, epichlorohydrin, the extract of Echinacea purpurea, thiotriazoline.Abstract
SUMMARY. In experiments on white male rats there were studied the regularities of the influence of epichlorohydrin on the mucous membrane of the stomach and on the depth of pits of pyloric stomach. We evaluated the possibility of using an extract of Echinacea purpurea and thiotriazoline for correction occurring changes. It was shown that epichlorohydrin causes a decrease in the depth of the pits of gastric mucosa pyloric part of the stomach that persists for fifteen days after the cessation of its administration. The degree of reduction of the depth gradually decreases. The use of the extract of Echinacea purpurea on the background of epichlorohydrin lowers the degree of reducing the depth of gastric pits caused by epichlorohydrin. Using thiotriazoline reduces the severity and shortens duration epichlorohydrin induced decrease the depth of the gastric pits.
References
Belyaeva YU. N. Monytorynh rasprostranennosty bolezney orhanov pyshchevarenyya y smertnosty ot nykh v Saratovskoy oblasty s yspolʹzovanyem HYS-tekhnolohyy / YU. N. Belyaeva, H. N. Shemetova, D. P. Khvorostukhyn // Praktykuyuchyy likar. – 2013. – № 3 (7). – S. 59–62.
Boyko T. Y. Epidemiolohiya ta chynnyky ryzyku khronichnykh nespetsyfichnykh zapalʹnykh zakhvoryuvanʹ kyshechnyka / T. Y. Boyko // Suchasna hastroenterolohiya. – 2013. – № 4 (72). – S. 129–133.
Strukturni zminy slyzovoyi obolonky i pidslyzovoho prosharku shlunka shchuriv, shcho vynykayutʹ pid vplyvom epikhlorhidrynu / S. M. Smirnov, M. L. Kuvenʹova, A. S. Smirnov, O. M. Rossomakhina // Ukrayinsʹkyy morfolohichnyy alʹmanakh. – 2013. – T. 11, № 4. – S. 74–76.
Solomentseva T. A. Khronycheskyy hastryt s pozytsyy kantserpreventsyy. Évolyutsyya predstavlenyy / T. A. Solomentseva // Suchasna hastroenterolohiya. – 2013. – № 4 (72), S. 135–140.
Zahryaznenye vozdushnoy sredy khlororhanycheskymy uhlevodorodamy v proyzvodstvakh polyvynylkhloryda y épykhlorhydryna / N. A. Taranenko, N. M. Meshchakova, O. M. Zhurba, V. V. Telezhkyn // Hyhyena y sanytaryya. – 2014. – № 4. – S. 47–51.
From gastroprotective to ulcerogenic effects of glucocorticoids: role of long-term glucocorticoid action / L. Filaretova, T. Podvigina, T. Bagaeva, O. Morozova // Curr. Pharm Des. – 2014. – № 20(7). – R. 1045–1050.
Esophagoprotection mediated by exogenous and endogenous melatonin in an experimental model of reflux esophagitis / P. C. Konturek, I. Brzozowska, A. Targosz [et al.] // J. Pineal Res. – 2013. – R. 46–57.
Apoptotic cell death in rat epididymis following epichlorohydrin treatment / I.C. Lee, K.H. Kim, S.H. Kim [et al.] // Hum. Exp. Toxicol. – 2013. – № 32 (6). – R. 640–646.
One-generation reproductive toxicity study of epichlorohydrin in Sprague-Dawley rats / I. S. Shin, N. H. Park, J. C. Lee [et al.] // Drug Chem Toxicol. – 2010. – № 33 (3). – R. 291–301.
Taurine zinc solid dispersions protect against coldrestraint stress-induced gastric ulceration by upregulating HSP70 and exerting an anxiolytic effect / C. Yu, X. T. Mei, Y. P. Zheng, D. H. Xu // Eur. J. Pharmacol. – 2015. – № 762. – R. 63–71.
