COMPARATIVE EFFECT OF GALLIC ACID AND QUERCETIN ON RENAL FUNCTION INDICATORS IN RATS UNDER THE EXPERIMENTAL DIABETES MELLITUS TYPE 2
DOI:
https://doi.org/10.11603/1811-2471.2016.v27.i3.6768Keywords:
diabetes mellitus type 2, diabetic nephropathy, gallic acid, quercetin.Abstract
SUMMARY. Scientists are constantly searching for the new molecules that can be used as bioactive functional ingredients to treat diabetes mellitus and its complications. In this context, flavonoids are the group of molecules under increasing interest. The aim of the study was to compare the effect of bioflavonoids quercetin and gallic acid on renal function in rats under experimental type 2 diabetes. Treatment with studied phenolic compounds significantly reduced renal dysfunction. However, quercetin showed higher activity that correlates with its higher antioxidant capacity.
References
Beneficial Effects of Quercetin on Obesity and Diabetes / L. Aguirre, N. Arias, M. T. Macarulla [et al.] // The Open Nutraceuticals Journal. – 2011. – № 4. – Р. 189–198.
Quercetin Ameliorates Diabetic Nephropathy in Rats via Modulation of Renal NA+, K+-ATP-ase Expression and Oxidative Stress / S. O. Bashir, M. D. Morsy, H. F. Sakr [et al.] // American Journal of Pharmacology and Toxicology. – 2014. – № 9 (1). – Р. 84–95.
Bazzano T. Renal biomarkers of male and female Wistar rats (Rattus norvegicus) undergoing renal ischemia and reperfusion / T. Bazzano, T. I. Restel, L. C. Porfirio [et al.] // Acta Cirúrgica Brasileira – 2015. – Vol. 30 (4) – Р. 277–288.
Standardization of renal function evaluation in Wistar rats (Rattus norvegicus) from the Federal University of Juiz de Fora's colony / B. B. A. de Castro, F. A. B. Colugnati, M. A. Cenedeze [et al.] // The Jornal Brasileiro de Nefrologia. – 2014. – № 36 (2). – P. 139–149.
Cho H. C. The Association between Serum GGT Concentration and Diabetic Peripheral Polyneuropathy in Type 2 Diabetic Patients // Korean Diabetes Journal. – 2010. – № 34. – P. 111–118.
Diseases of Renal Parenchyma / edited by M. Sahay. – InTech, 2012. – 304 р.
El-Gohary O. A. Effect of Exercise and Quercetin on Obesity Induced Metabolic and Renal Impairments in Albino Rats / O. A. El-Gohary, N. I. Hussien // Journal of Physiology and Pharmacology Advances. – 2015. – № 5 (3). – Р. 589–602.
Global report on diabetes. World Health Organization World Health Organization 2016. WHO Library Cataloguingin-Publication. Data available on the WHO website: http://www.who.int.
Relationship between gamma-glutamyl transferase and glucose intolerance in first degree relatives of type 2 diabetics patients / S.Haghighi, M. Amini, Z. Pournaghshband [et al.] // International Journal of Research in Medical Sciences. – 2011. – № 16 (2). – Р. 123–129.
Preventive Effects of Flavonoids on Alloxan-Induced Diabetes Mellitus in Rats / A. Lukacinova, J. Mojzis, R. Benacka [et al.] // Acta Veterinaria Brunensis. – 2008. – № 77. – Р. 175–182.
Quercetin Protects against Diabetes-Induced Exaggerated Vasoconstriction in Rats: Effect on Low Grade Inflammation / M. F. Mahmoud, N. A. Hassan, H. M. El Bassossy [et al.] // J. Res Med Sci. – 2011. – № 16(2). – Р. 123–129.
Urinary Protein Profiles in a Rat Model for Diabetic Complications / D. M. Schlatzer, J.-E. Dazard, M. Dharsee [et al.] // Molecular & Cellular Proteomics. – 2009. – № 8 (9). – Р. 2145–2158.
Sun K. Serum Gamma - Glutamyltransferase Is Associated with Albuminuria: A Population-Based Study / K. Sun, L. Feng, L. Diaozhu // PLoS One. – 2014. – № 9 (12). DOI:10.1371/journal.pone.0114970.
Tervaert T. W. C. Pathologic Classification of Diabetic Nephropathy / T. W. C. Tervaert, A. L. Mooyaart, K. Amann // Journal of American Society of Nephrology. – 2010. – № 21. – Р. 556–563.
Umadevi S. Regulatory mechanism of gallic acid against advanced glycation end products induced cardiac remodeling in experimental rats / S. Umadevi, V. Gopi, V. Elangovan [et al.] // Chemico-Biological Interactions. – 2014. – № 208. – Р. 28–36.
Gamma-Glutamyl Transferase is Related to Microalbuminuria in Diabetic Patients / A. Ünal, İ. Çerçi, E. Doğan [et al.] // Türk Nefroloji Diyaliz ve Transplantasyon. – 2014. – № 23 (3). – Р. 217–222.
Klinichna biokhimiya : navch. posib. / za red. O. P. Tymoshenko. – K. : Vyd-vo «Profesional», 2005. – 288 s.
Pat. 38466 Ukrayina, MPK G09B 23/28 (2008.01). Sposib modelyuvannya tsukrovoho diabetu 2 typu u shchuriv / O. I. Hladkykh, V. V. Poltorak, N. S. Krasova ta in.; zayavnyk i patentovlasnyk DU «Instytut problem endokrynnoyi patolohiyi im. V. YA. Danylevsʹkoho» AMN Ukrayiny. – № U 200810259; zayavl. 11.08.2008 r. Opubl.
01.2009 r. – Byul. № 1. – 4 s.
