FUNCTIONAL LIVER STATUS IN PATIENTS WITH COMORBID COURSE OF OSTEOARTHROSIS AND OBESITY DEPENDING ON THE NONSTEROIDAL ANTI-INFLAMMATORY DRUG
DOI:
https://doi.org/10.11603/1811-2471.2016.v26.i2.6255Abstract
SUMMARY. In order to clarify the peculiarities of liver lesions in patients with osteoarthrosis (OA) and obesity against
the ground of nonsteroidal anti-inflammatory drugs (NSAIDs) indication (nimesulide, meloxicam, diclofenac, paracetamol,
ibuprofen) 48 patients have been examined with OA of the knee and femoral joints and obesity of I-III degrees. Maximal
hepatotoxic effect after 2 week administration for patients with OA and obesity has been found to be manifested in case
of paracetamol, diclofenac, nimesulide, ibuprofen indications; meloxicam demonstrates a minimal hepatotoxic effect
and can be recommended in case of this comorbidity.
Key words : osteoarthrosis, obesity, NSAIDs.
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