THE PECULIARITIES OF CONNECTIVE TISSUE AND INFLAMMATORY CYTOKINES METABOLISM IN PATIENTS WITH OSTEOARTHRITIS, COMORBID HYPERTENSION AND OBESITY
DOI:
https://doi.org/10.11603/1811-2471.2016.v26.i2.6254Abstract
SUMMARY. In the paper the research results of changes of the connective tissue and inflammatory cytokines
metabolism in patients with comorbid osteoarthritis, essential hypertension and obesity are presented. The osteoarthritis
course is accompanied by increased activity of systemic inflammation, the intensity of systemic inflammation is
significantly higher in case of the presence of comorbidities: hypertension and obesity. In patients with osteoarthritis the
content of inflammatory cytokines in the blood is likely higher and increases even more when combined with comorbid
obesity.
KEY WORDS: osteoarthritis, arterial hypertension, obesity, connective tissue, inflammatory cytokines.
References
Bereznyakov Y. H. Osteoartroz, arteryalʹnaya
hypertenzyya y ozhyrenye: problema komorbydnosty /
Y. H. Bereznyakov, Y. V. Korzh // Mezhdunarodnyy med.
zhurnal. – 2012. – № 4. – S. 78–81.
Holovach Y. YU. Osteoartryt: sovremennye
fundamentalʹnye y prykladnye aspekty patoheneza
zabolevanyya / Y. YU.Holovach // Bolʹ. Sustavy. Pozvo-
nochnyk. – 2014. – № 3 (15). – S. 54–58
Dubykov A. Y. Osteoartroz: staraya boleznʹ,
novye podkhody / A. Y. Dubykov // Sovr. revmatolohyya.
– № 2. – S. 82–83.
Opimakh O. I Vyvchennya aktyvnosti systemnoho za-
palennya u khvorykh na osteoartroz-asotsiyovanyy z ozhy-
rinnyam / O. I. Opimakh // Patolohiya. – 2010. – № 3 (7). –
S. 110–112
Tanas O. V. Dynamika pokaznykiv tsytokinovoho ta
oksydantnoho homeostazu pry likuvanni diatsereyinom u
patsiyentiv z osteoartrozom ta komorbidnymy zakhvoryu-
vannyamy / O. V. Tanas, O. S. Khukhlina // Visnyk problem bi-
olohiyi i medytsyny. – 2014. – № 3, T. 2 (111). – S. 241–245.
Tanas O. V. Suchasna terapiya osteoartrozu za ko-
morbidnosti z arterialʹnoyu hipertenziyeyu ta ozhyrin-
nyam / O. V. Tanas, O. S. Khukhlina // Materialy 96-yi pidsumko-
voyi naukovoyi konferentsiyi profesorsʹko-vykladatsʹkoho
personalu Bukovynsʹkoho derzhavnoho medychnoho uni-
versytetu (Chernivtsi, 16, 18, 23 lyutoho 2015 r.). – Cherniv-
tsi : BDMU, 2015. – S. 107–108.
Increased interleukin-1b gene expression in
peripheral
blood leukocytes is associated with increased
pain and predicts risk for progression of symptomatic knee
osteoarthritis / M. Attur, I. Belitskaya-Levy, C. Oh [et. al] //
Arthritis Rheum. – 2011. – Vol. 63, № 7. – P. 1908–1917.
Bijsma M. Osteoarthritis: an update with relevance
for clinical practice / M. Bijsma, F. Berenbaum, F. P. Lafeber
// Lancet. – 2011. – Vol. 377. – P. 2115–2126.
Osteoartritis: a progressive disease with chaning phenotypes
/ S. Casteda, J. A. Roman-Blas, R. Largo, G. Harrero-
Beaumont // Rheumatology. – 2013. – №6. – S. 258–260.
Sokolove J. Role of inflammation in the pathogenesis
of osteoarthritis: latest finding and interpretations /
J. Sokolove, Ch. M. Lepus // Ther. Adv. Musculoskel. Dis. –
– Vol. 5, № 2. – P. 77–94.
Goldring M. B. Inflammation in osteoartritis /
M. B. Goldring, M. Otero // Curr. Opin.Rheumatol. – 2011. –
Vol. 23, № 5. – P. 471–478.
Magliano M. Obesity and arthritis / M. Magliano //
Menopause Int. – 2008. – Vol. 14. – R. 149–154.
Role of proinflammatory cytokines in the
pathophysiology of osteoarthritis / M. Kapoor [et all.] //
Nat. Rev. Rheumatol. – 2011. – Vol. 7, № 1. – P. 33–42.