THE DESQUAMATION OF THE ENDOTHELIOCYTES OF THE ARTERIES OF LOWER LIMBS IN EXPERIMENTAL HYPERURICEMIA IN RATS OF BEFORE REPRODUCTIVE AND REPRODUCTIVE AGE
DOI:
https://doi.org/10.11603/1811-2471.2015.v24.i4.5817Abstract
Summary. In the analysis of the features of endotheliocytes desquamation among animals of before reproductive and reproductive age in conditions of hyperuricemia it was defned that the number of desquamated endothelial cells increases signifcantly up to the 30th day of experiment and prevails among rats of reproductive age.
The remodeling of the blood fow shows up by thickening of the vascular wall due to the hyperplasia and hypertrophy of the leiomyocytes and lymphocytic and macrophage infltration of the adventitia.
Key words: hyperuricemia, desquamated endotheliocytes, remodeling, arteries of the lower limbs.
References
Gagliardi A. C. Uric acid: A marker of increased cardiovascular
risk / A. C. Gagliardi, M. N. Miname, R. D. Santos
// Atherosclerosis. – 2009. – Vol. 202, № 1. – P. 11–17.
Zavhorodnyaya A. N. Strukturnye osobennosty sosudystoho
éndotelyya pry ostrykh tserebralʹnykh yshemyyakh
/ A. N. Zavhorodnyaya // Mezhdunarodnyy medytsynskyy
zhurnal. – 2013. – № 2. – S. 21–24.
Lyubyn A. V. Funktsyonalʹnoe sostoyanye éndotelyotsytov
pry élektrotravme v éksperymente / A. V. Lyubyn
// Aspyrant·skyy vestnyk Povolzhʹya. – 2013. – № 1–2. –
S. 192–194.
Boos C. J. The relationship of circulating endothelial
cells to plasma indices of endothelial damage/dysfunction
and apoptosis in acute coronary syndromes: implications
for prognosis / C. J. Boos, B. Balakrishnan, A. D. Blann //
Thromb. Haemost. – 2008. – № 6. – R. 1841–1850.
Závada J. Circulating endothelial cells and circulating
endothelial progenitors in kidney disease – victims, witnesses,
or accomplices? / J. Závada, L. Kideryová, R. Pytlík //
Folia Biol (Praha). – 2008. – № 54 (3). – R. 73–80.
Dysfunktsyya éndotelyya. Patohenetycheskoe znachenye
y metody korrektsyy / pod. red. N. N. Petryshcheva. –
SPb. : YYTS VMA, 2007. – 296 s.
Kato M. Status of endothelial dependent vasodilatation
in patients with hyperuricemia / M. Kato, I. Hisatone,
Y. Tomikura // Am. J. Cardiol. – 2005. – Vol. 96. –
P. 1576–1578.
Takayama S. Uric acid is an independent risk factor
for carotid atherosclerosis in a Japanese elderly
population without metabolic syndrome / S. Takayama,
R. Kawamoto, T. Kusunoki // Cardiovasc. Diabetol. – 2012. –
Vol. 11. – P. 2–9.
Patent 25012 U, Ukrayina. Sposib vyznachennya vilʹnotsyrkulyuyuchykh
endotelialʹnykh klityn u krovi / V. V. Sivak,
N. V. Tymofiyeva, O. B. Donnyk ta in. – № 200702080;
zayavl. 27.02.07 ; opubl. 25.07.07., Byul 6.
Synyachenko O. V. Éndotelyalʹnaya dysfunktsyya
sosudov y lechenye bolʹnykh podahroy / O. V. Synyachenko,
H. A. Yhnatenko, E. A. Subbotyna // Ukrayinsʹkyy terapevtychnyy
zhurnal. – 2007. – № 4. – S. 18– 22.
Patent Ukrayiny № 97949 UA, G09B23/28,
A61K35/14 Sposib modelyuvannya hiperurykemiyi / Bodnar
YA. YA., Kripka O. I., Yuryk I. I. / DVNZ «Ternopilʹsʹkyy
derzhavnyy medychnyy universytet imeni I. YA. Horbachevsʹkoho
MOZ Ukrayiny» / Opubl. 10.04.2015 ; Byul. №7.
Yvashkyn V. T. Klynycheskoe znachenye oksyda azota
y belkov teplovoho shoka / V. T. Yvashkyn, O. M. Drapkyna.
– M. : HÉOTAR-Medya, 2011. – 376 s.
