THROMBOCYTE-ENDOTHELIAL ADHESION MOLECULE AS PREDICTOR OF ENDOTHELIAL DYSFUNCTION AT ARTERIAL HYPERTENSION WITH DIABETES MELLITUS TYPE II
DOI:
https://doi.org/10.11603/1811-2471.2015.v24.i4.5816Abstract
Summary. The role of thrombocyte-endothelial adhesion molecule sPECAM-1 in endothelial dysfunction in patients with arterial hypertension and diabetes mellitus type ІІ is analysed in the article.
It was set the reliable correlation between the sPECAM-1 level, glycemia and insulin resistance index. The decline of tensility, elasticity, local infexibility and increase of pulse wave were accompanied by forced expression of adhesion molecule. Positive correlation was verifed between sPECAM-1 concentration and shear stress in endothelium dependent vasodilation, and, also, negative correlation between sPECAM-1 increasing and endothelium sensitivity in vasodilatation test. The diagnostic value of thrombocyte-endothelial adhesion molecule sPECAM-1 for endothelial dysfunction prognosis was analysed.
Key words: endothelial dysfunction, arterial hypertension, diabetes mellitus, adhesion molecule, sPECAM-1.
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