COMPARISON OF THE INFLUENCE OF ANTICONVULSANTS WITH GABA AND GLUTAMATERGIС ACTION ON THE BEHAVIORAL RESPONSES AND LOCOMOTOR FUNCTION IN RATS IN AN EXPERIMENT
DOI:
https://doi.org/10.11603/1811-2471.2015.v24.i4.5815Abstract
SUMMARY. In the experimental study on nonlinear white rats, the effect of anticonvulsants with different mechanisms of infuence on the behavioral responses and coordination of movements of animals was studied. Intragastric administration of Carbamazepine (125 mg/kg) reduced horizontal (by 88.4 %) and vertical (by 89.7 %) motor activities. Carbamazepine had the greatest negative impact on locomotor function as well, the latent time decrease of which was reduced in rotorod-test by 65.28 %. The least negative effect on the horizontal locomotor activity provided gabapentin (100 mg/kg). The study revealed that lamotrigine (30 mg/kg) as a blocker of glutamate release, as well as topiramate (30mg/kg) also had the least impact on horizontal locomotor activity, reducing it to 55.4% and 65.61% respectively. Thus, anticonvulsants with predominantly GABAergic action had a more depressing effect on the coordination of movements and behavioral responses in animals.
KEY WORDS: anticonvulsants, behavioral responses, GABA, glutamate.
References
Oldenkamp A. P. Newer antiepileptic drugs and
cognitive issues / A. P. Aldenkamp, M. D. Krom, R. Reijs //
Epilepsia. – 2003. – № 44 (4). – R. 21–29.
Hekht A. B. Otsenka kachestva zhyzny bolʹnykh s
épylepsyey / A. B. Hekht : IX konhress «Chelovek y Lekarstvo
». – M., 2002.
Brody M. Techenye y ratsyonalʹnaya terapyya
épylepsyy / M. Brody // Mezhdunar. nevrol. zhurnal. –
– № 4. – S. 72–83.
Lundberg S. Rolandic epilepsy: a challenge in terminology
and classification / S. Lundberg, O. Eeg-Olofsson
/ European Journal of Paediatric Neurology. – 2003. –
№ (7). – R. 239–241.
Treatment of interictal epileptiform discharges can
improve behavior in children with behavioral problems and
epilepsy / R. Pressler, R. Robinson, G. Wilson, C. Binnie //
J. Pediatr. – 2005. – № 146. – R. 112–117.
Effects of gabapentin and topiramate in primary
rat astrocyte cultures / V. Cardile, A. Pavone, M. Renis [et
al.] // Neuroreport. – 2001. – № 12. – R. 1705–1708.
Effect of lamotrigine, oxcarbazepine and topiramate
on cognitive functions and oxidative stress in PTZkindled
mice / N. B. Agarwal, N. K. Agarwal, P. K. Mediratta,
K. K. Sharma // Seizure. – 2011. – № 20(3). – R. 257–262.
Effects of conventional anticonvulsant drugs on
generalized tonic-clonic seizures in Noda epileptic rats /
M. Inoue, A. Yamamoto, Y. Kaneko [et al.] // Epilepsy Res. –
– № 108 (7). – R. 1158–1167.
Luo Z. The effects of antiepileptic drug valproic acid
on apoptosis of hippocampal neurons in epileptic rats /
Z. Luo, Y. Fang, L. Zhang // Pak J. Pharm. Sci. – 2015. – № 28
(1 Suppl). – R. 319–324.
Abuladze G. The study of emotionality in rats and
mice in behavioral and pharmacological experiments, the
method of «open field» // G. Abuladze Biology. – 1983. –
№ 9 (3). – R. 156–165.
Buresh YA. Metodyky y osnovnye éksperymenty
po yzuchenyyu moz·ha y povedenyya / YA. Buresh, O. Bureshova,
D. P. Khʹyuston. – M. : Vysshaya shkola, 1991. – S. 175–
, 119–122.
Dunham N. W. A note on a simple apparatus for
detecting neurological defi cit in rats and mice / N. W. Dunham,
T. S. Miya // J. Amer. Pharm. Assoc. Sci. Ed. – 1957. –
№ 46. – P. 208–209.
