CHANGES OF HUMORAL IMMUNITY UNDER MENSTRUAL CYCLE DISORDERS IN WOMEN WITH TUBERCULOSIS
DOI:
https://doi.org/10.11603/1811-2471.2015.v24.i4.5808Abstract
Summary. Research results of humoral immunity state in patients with menstrual irregularities, suffering from tuberculosis are presented. It is shown that the menstrual cycle (MC) in a cohort of women undergoes signifcant violations by reducing the functional ability of B-lymphocytes (CD20+) by 46.5 %, despite a compensatory increase in their relative amount, functional capacity and reduction of production of major classes of immunoglobulins by 5.6 %. It is proved that IgG lowering by 33.2 % has a predictive value and negative impact on the fow of MC. Rising concentrations of IgM by 53.8 % and IgA by 81.4 % confrmed new revenue of antigens into the bloodstream.
Key words: tuberculosis, menstrual cycle, humoral immunity, diagnosis.
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