The impact of exclusion beta 1-adrenergic receptors associative cortex of adult rats on autonomic regulation of the heart rhythm in conditions of low atmospheric pressure
DOI:
https://doi.org/10.11603/1811-2471.2015.v24.i4.5798Abstract
Summary. The literature reports on the possibility of blocking beta1-adrenergic receptor by selective drug nebivolol. But there is no data on the effects of blocking beta1-adrenergic receptors in the associative cortical felds to autonomous regulation of heart rate. However, there is a possibility for modeling hypobaric and hypoxic conditions in the experiment. The aim of the experiment was to determine the functional consequences of blocking beta1-adrenergic receptors in the associative cortex of adult rats under low atmospheric pressure. In the experiment, the blocking of beta1-adrenergic receptors in the associative cortex of adult rats under low atmospheric pressure revealed the involvement of beta1-adrenergic structures in left associative cortical feld to the neural circuits that provide parasympathetic infuence on the heart rate. This effect was different from the result of nebivolol action at analoges experiment under the normal atmospheric pressure.
Key words: beta1-adrenergic receptors, autonomus regulation of heart rate, decreased atmospheric pressure.
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