L-arginine and recsode impruve liver status in experimental peritonitis
DOI:
https://doi.org/10.11603/1811-2471.2015.v23.i2-3.5273Abstract
SUMMARY. The aim of the investigation was to study the influence of the precursor synthesis of nitric oxide – L-arginine and recombinant superoxide dismutase (recsode) on the liver status in experimental acute peritonitis. L-arginine ("Sigma", USA, the intraperitoneal administration, 25 mg/kg, 30 minutes before and 12, 24 and 36 h after modeling peritonitis) attenuated the processes of lipid peroxidation, normalized of antioxidative activity and the level of mitochondria enzymes, which accompanied by the increase of nitric oxide synthesis in the liver. The drug of superoxide dismutase – recsode (SODrec, RF, the intraperitoneal administration, 0.05 mg/kg, the same scheme of administration) contributed to reduction of experimental animals indices of lipid peroxidation, reduction of endogenous intoxication, activated antioxidant system and mitochondrial enzyme activity.
KEY WORDS: acute peritonitis, liver, L-arginine, recsode.References
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