Dynamics of syndrome endogenous intoxication under conditions polytrauma and correction of carbacetam
DOI:
https://doi.org/10.11603/1811-2471.2015.v23.i2-3.5238Abstract
Summary. Application Carbacetam from the date of trauma for 14 days at a dose of 5 mg per kilogram of animal accompanied by a significant reduction in endogenous intoxication, which is manifested in normalization of serum fractions MMM254 through 14–28 days post-traumatic period faction MMM280 – after 14 and 28 days and EII value – in all terms of observation. In terms of application Carbacetam content in blood serum fractions 14–28 days via MMM280, MMM254 faction – after 21 and 28 days and EII – 21 days is statistically significantly lower than in animals without correction.
Key words: polytrauma, endogenous intoxication, Carbacetam.References
Yzbrannye aspekty patoheneza y lechenyya travmatycheskoy bolezny / V. N. Elʹskyy, V. H. Klymovytskyy, S. E Zolotukhyn [y dr.] – Donetsk : OOO “Lebedʹ”, 2002. – 360 s.
Osobennosty yzmenenyy aktyvnosty oksyreduktaz, soderzhanyya malonovoho dyalʹdehyda y molekul sredney massy v krovy bolʹnykh s cherepno-moz·hovoy travmoy razlychnoy stepeny tyazhesty / D. E. Yvanov, D. M. Puchynʹyan, V. H. Nynelʹ [y dr.] // Klyn. lab. diahnostyka. – 2001. – № 5. – S. 40–41.
Rannyaya dyahnostyka syndroma polyorhannoy dysfunktsyy u postradavshykh s polytravmoy / S. V. Hayduk, V. V. Boyaryntsev, S. V. Havrylyn [y dr.] // “Polytravma: dyahnostyka, lechenye y profylaktyka oslozhnenyy”. – Materyaly II Vserossyyskoy nauchno-praktycheskoy konferentsyy. – Lenynsk-Kuznetskyy, 2007. – S. 40.
Éndotoksykoz pry tyazheloy sochetannoy travme / Y. A. Eryukhyn, S. V. Havrylyn, N. S. Nemchenko [y dr.] // Vestn. khyrurhyy. – 2001. – T. 160, № 5. – S. 120–124.
Kozak D. V. Vplyv karbatsetamu na antyoksydantnyy-prooksydantnyy balans tkanyny sertsya, lehenʹ i pechinky v dynamitsi politravmy / D. V. Kozak // Shpytalʹna khirurhiya. – 2014. – № 1 (65). – S. 40–42.
Kozak D. V. Vplyv karbatsetamu na dynamiku pokaznykiv tsytolizu ta vmist tsyrkulyuyuchykh imunnykh kompleksiv v umovakh politravmy / D. V. Kozak // Visnyk naukovykh doslidzhenʹ. – 2014. – № 2 (75). – S. 80–82.
Kozak D. V. Strukturni zminy deyakykh vnutrishnikh orhaniv tvaryn iz modelʹovanoyu politravmoyu za umov korektsiyi karbatsetamom / D. V. Kozak, K. S. Volkov // Naukovyy visnyk Uzhhorodsʹkoho universytetu, seriya «Medytsyna». – 2014. – Vyp. 2 (50). – S. 3–6.
Pat. 63997 Ukrayina, MPK G 09 V 23/28. Sposib modelyuvannya politravmy / Kozak D. V.; zayavnyk i patentovlasnyk Ternopilʹsʹkyy derzhavnyy medychnyy universytet imeni I. YA. Horbachevsʹkoho. – № u 201104110 ; zayavl. 05.04.11 ; opubl. 25.10.11, Byul. 20.
Komyssarov Y. V. Korrektsyya lyhandamy hlutamatnykh retseptorov narushenyy mnestycheskykh funktsyy pry ékspe-rymentalʹnoy fokalʹnoy yshemyy kory moz·ha / Y. V. Komyssarov, A. V. Zhuravskyy, V. E. Hmyro // Zhurnal AMN Ukrayiny. – 2003. – T. 9, № 2. – S. 238–249.
Metody doslidzhennya endohennoyi intoksykatsiyi orhanizmu : metodychni rekomendatsiyi / M. A. Andreychyn, M. D. Bekh, V. V. Demʺyanenko [ta in.]. – K., 1998. – S. 10–13.
Sposob dyahnostyky éndohennoy yntoksykatsyy / A. A. Tohaybaev , A. V. Kurhuzkyn , R. M. Rykun, R. M. Krybzhanova // Lab. delo. – 1988. – T. 4, № 9. – S. 22–24.
Kozak D. V. Lipid peroxidation, antioxidant defence, endogenous intoxication and cytolysis variations in early and late manifestations of traumatic disease / D. V. Kozak // Journal of Health Sciences. – 2013. – Vol. 3, № 4. – R. 108–117.
Burchynskyy S. H. Neyroprotektsyya kak kompleksnaya farmakoterapevtycheskaya y farmakoprofylaktycheskaya stratehyya / S. H. Burchynskyy // Therapia. – 2008. – № 2. – S. 5–8.
