Dynamics of lipid peroxidation and antioxidant protection indicators of liver tissue in the early period after the application of multiple injuries in animals with chronic hepatitis
DOI:
https://doi.org/10.11603/1811-2471.2015.v23.i2-3.5233Abstract
Summary. In the context of polytrauma in the early period of traumatic disease is observed intensification of lipid peroxidation, which is manifested by an increase of content in the liver tissue of TBA-reactive products of lipid peroxidation compared to the control group. Against the background of concomitant chronic hepatitis and polytrauma indicator is much higher than in the group of animals without chronic hepatitis at 1 and 7 days after injury, but its amplitude deviations less than the animals without chronic hepatitis. In the context of polytrauma occurs in the liver tissue significantly increase SOD activity, decrease - catalase and magnitude API, which reach their maximal after 3 days of violations and further changed towards the norm, but it does not reach. Against the background of concomitant chronic hepatitis and polytrauma they change analogous to the vector, but with a smaller amplitude. Their maximum violation occurs after 1–3 days and remained at the same level up to 7 days.
Key words: polytrauma, chronic hepatitis, liver, lipid peroxidation, antioxidant protection.
References
Andreeva L. Y. Modyfykatsyya metoda opredelenyya perekysey lypydov v teste s tyobarbyturovoy kyslotoy / L. Y. Andreeva, L. A. Kozhemyakyn, A. A. Kyshkun // Lab. delo. – 1988. – № 11. – S. 41–43.
Antyoksydantno-prooksydantnyy indeks syrovatky krovi shchuriv z eksperymentalʹnym stomatytom i yoho korektsiya zubnymy eliksyramy / A. P. Levytsʹkyy, V. M. Pochtar, O. A. Makarenko, L. I. Hrydina // Odesʹkyy med. zhurn. – 2006. – № 1. – S. 22–25.
Borys R. M. Osoblyvosti peroksydnoho okysnennya lipidiv u period hostroyi reaktsiyi na poyednanu kranioskeletnu travmu / R. M. Borys // Aktualʹnye problemy transportnoy medytsyny. – 2013. – № 2 (32). – S. 149–153.
Volotovsʹka N. V. Rolʹ hemichnoyi hipoksiyi v patohenezi porushenʹ zhovchoutvoryuvalʹnoyi i zhovchovydilʹnoyi funktsiy pechinky na tli skeletnoyi travmy v rannʹomu posttravmatychnomu periodi / N. V. Volotovsʹka, A. A. Hudyma // Zdobutky klinichnoyi i eksperymentalʹnoyi medytsyny. – 2011. – № 2(15). – S. 31–33.
Volotovsʹka N. V. Dynamika pokaznykiv vilʹnoradykalʹnoho okyslennya i antyoksydantnoho zakhystu tkanyn pechinky v umovakh politravmy / N.V. Volotovsʹka // Medychna khimiya. – 2011. – T. 13, № 4(49). – S. 224.
Hudyma A. A. Vplyv lansoprazolu, metronidazolu i klarytromitsynu na funktsionalʹnyy stan pechinky i yoho korektsiya tiotryazolinom v umovakh khronichnoho eksperymentalʹnoho hepatytu / A. A. Hudyma, V. V. Pidhirnyy // Zaporizʹkyy medychnyy zhurnal.– 2007. – № 5. – S. 33–37.
Dzyuba D. A. Pokazately aktyvatsyy apoptoza v techenyy polytravmy tyazheloy stepeny / D. A. Dzyuba, Y. R. Malysh, L. V. Z·hrzheblovskaya // Ukrayinsʹkyy zhurnal ekstremalʹnoyi medytsyny imeni H. O. Mozhayeva. – 2008. – T. 9, № 1. – S. 53–58.
Kozak D. V. Dynamika pokaznykiv antyoksydantnoho zakhystu u vidpovidʹ na politravmu / D. V. Kozak // Shpytalʹna khirurhiya. – 2012. – № 3 (59). – S. 60–64.
Kozak D. V. Osoblyvosti funktsionalʹnoho stanu pechinky v dynamitsi rannʹoho posttravmatychnoho periodu politravmy / D. V. Kozak // Biomedical and Anthropology. – 2013. – № 20. – S. 97–99.
Aktualʹni pytannya orhanizatsiyi i nadannya urhentnoyi dopomohy pry torakoabdominalʹniy travmi / YA. H. Kolkin, I. V. Mukhin, V. V. Khatsko [ta in.] // Shpytalʹna khirurhiya. – 2004. – № 4. – C. 145–148.
Metod opredelenyya aktyvnosty katalazy / M. A. Korolyuk, L. Y. Yvanova, Y. H. Mayorova, V. E. Tokarev // Laboratornoe delo. – 1988. – № 1. – S. 16–19.
Pat. na korysnu modelʹ 30028 Ukrayina MIZH 2006 G 09 V 23/00. Sposib modelyuvannya politravmy / T. YA. Sekela, A. A. Hudyma (Ukrayina) ; zayavnyk i patentovlasnyk Ternopilʹsʹkyy med. universytet. – № U 2007 10471 ; zayavl. 21.09.2007 ; opubl. 11.2.08; Byul. № 3–4.
Seleznev S. A. Yzmenenyya funktsyy vnutrennykh orhanov pry tyazheloy mekhanycheskoy travme / S. A. Seleznev, S. F. Bahnenko, YU. B. Shapot // Narushenyya funktsyy moz·ha y vnutrennykh orhanov pry sochetannoy mekhanycheskoy travme y termynalʹnykh sostoyanyyakh : materyaly k “kruhlomu stolu” / SPb. : NYY skoroy pomoshchy ym. Y.Y. Dzhanelydze. – SPb., 2001. – 18 s.
Chevary S. Rolʹ superoksyddysmutazy v okyslytelʹnykh protsessakh kletky y metod opredelenyya ee v byolohycheskykh materyalakh [Tekst] / S. Chevary, Y. Chaba, Y. Sokey // Lab. delo. – 1985. – № 11. – S. 678–681.
Shcherbyna M. B. Innovatsiyi v likuvanni khronichnykh medykamentoznykh ta alkoholʹnykh hepatytiv / M. B. Shcherbyna // Hastroenterolohiya. – 2012. – № 429. – S. 48–50.
Effects of dithiocarb and (+) cyanidanol-3 on the CCL4 alcohol induced fibrosis of rat liver / C. P. Siegers, V. Voipel, G. Schel [et al.] // Connective Tissue Norn. and Fibrotis. Hum. Liver. Stuttgart. New-York. – 1982. – Vol. 3. – P. 244–245.
Peden M. World report on road traffic injury prevention. / M. Peden, R. Scurfield, D. Sleet [et al.] // Geneva, Switzerland: World Health Organization; 2004.
