HETEROMETALLIC COMPLEXES OF GERMANIUM(IV) WITH GLUCONIC ACID: SYNTHESIS AND SCREENING OF POTENTIAL ANTIHYPOXANTS
DOI:
https://doi.org/10.11603/1811-2471.2026.v.i1.16132Keywords:
heterometallic complexes of germanium (IV), synthesis, screening, antihypoxants, hypoxia with hypercapniaAbstract
SUMMARY. For the first time, 6 germanium(IV) compounds with gluconic acid and the following biometals were synthesized and studied in a screening format: Mg, Mn, Co, Ni, Cu, Zn.
The aim – to conduct a targeted synthesis of new heterometallic germanium(IV) complexes based on gluconic acid and to conduct a primary pharmacological screening of antihypoxants among them in the model of confined space hypoxia (CSP).
Material and Methods. The experimental part of the study was performed on 64 outbred white mice weighing 18-21 g. CSP was modelled as one of the forms of acute hypoxic hypoxia with progressive hypercapnia by placing animals in isolated sealed volumes (1 dm³) for 40 min. Mexidolum (armadin) served as the reference drug, which has pronounced antihypoxic, antiischemic and antioxidant effects. The control group consisted of animals with untreated CSP, which received a similar volume of 0.9 % sodium chloride solution.
Results. It was experimentally proven that among the 6 synthesized and studied novel compounds in the primary screening according to the criteria for assessing the effectiveness of potential antihypoxants (life expectancy in a hermetic volume, relative life extension, antihypoxic protection coefficient and clinical course of hypoxic state), the highest activity was exerted by hexaaquazinc dihydroxy-µ-bis(gluconato)digermanate(IV) under the laboratory code Biogerm-Zn, which by all indicators significantly (P<0.05) exceeds the antihypoxic effectiveness of the reference drug.
Conclusions. The conducted comparative analysis of the antihypoxic properties of the studied compounds allowed us to establish the pharmacophore of the compound – the leader, which is zinc. The obtained results are an experimental justification of the prospects for further research of the potential antihypoxant Biogerm-Zn under conditions of acute hypoxic hypoxia with progressive hypercapnia.
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Accepted 2026-04-09
Published 2026-04-22
