ADDITIVE TECHNIQUES AND BIOPRINTERS IN PHARMACEUTICAL INDUSTRY: A REVIEW OF MODERN APPLICATIONS
DOI:
https://doi.org/10.11603/1811-2471.2026.v.i1.16128Keywords:
additive techniques, 3D printing, medicines and cosmetics products manufacture techniques, personalized medicineAbstract
SUMMARY. The aim – to search in informational-scientific and sciencemetric data bases such as Scopus, Web of Science and PubMed by the key words: additive techniques, 3D printing, medicines, cosmetics, manufacturing, personalized medicine, for systematizing of scientific professional literature data in regarding the implementation of additive techniques and bioprinting in the production of medicinal and cosmetic products, assessing the advantages and constraints of the techniques as well as to prognose the ways of future research directions in this field.
Material and Methods. The source material for the study was derived from scientific publications of domestic and foreign authors presented in professional peer-reviewed publications and electronic scientific databases dedicated to application of additive techniques in pharmaceutical and cosmetic industries. For our research we used the methods of systemic analysis, comparative and generalization of literary sources, as well as logical and structural processing of information.
Results. The modern healthcare system is undergoing a fundamental transformation shifting the focus on personalized medicine. The adaptation of therapy to the individual needs of patients in context of pharmacogenetics, metabolism and physiological characteristics has become the mainstream of the pharmaceutical industry.
The techniques are focused on layer-by-layer objects based on digital models for designing medicines with complex geometry, controlled active substance release, and the ability to combine several active ingredients in a single dose. Inkjet printing, fused deposition modeling (FDM), selective laser sintering (SLS), stereolithography (SLA) and pressure-assisted microsyringe (PAM) are the techniques currently being practically tested by pharmacists and cosmetologists for the above purposes.
Conclusions. We summarized current information on application of additive techniques in manufacture of medicines and cosmeceutical products. 3D printing has been shown to enable to create personalized medicinal and cosmetic formulations with controlled structure and release profile. Bioprinting has been proven to boost the potential of preclinical screening and alternative safety models, particularly in cosmetology and regenerative medicine. However, widespread adoption of these techniques is hampered by technological and regulatory constraints.
References
Hockings JK, Pasternak AL, Erwin AL, Mason NT, Eng C, Hicks JK. Pharmacogenomics: An evolving clinical tool for precision medicine. Cleve Clin J Med. 2020 Feb; 87(2):91-99. DOI: 10.3949/ccjm.87a.19073.
Lepowsky E, Tasoglu S. 3D printing for drug manufacturing: A perspective on the future of pharmaceuticals. Int J Bioprint. 2017; 4(1):119. Published 2017 Sep 25. DOI:10.18063/IJB.v4i1.119
Wang S, Chen X, Han X, Hong X, Li X, Zhang H, Li M, Wang Z, Zheng A. A Review of 3D Printing Technology in Pharmaceutics: Technology and Applications, Now and Future. Pharmaceutics. 2023; 15(2):416. DOI: 10.3390/pharmaceutics15020416.
Tabriz AG, Fullbrook DHG, Vilain L, et al. Personalised Tasted Masked Chewable 3D Printed Fruit-Chews for Paediatric Patients. Pharmaceutics. 2021; 13(8):1301. Published 2021 Aug 20. DOI:10.3390/pharmaceutics13081301
Lafeber I, Ruijgrok EJ, Guchelaar HJ, Schimmel KJM. 3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?-A Scoping Review. Pharmaceutics. 2022; 14(2):416. Published 2022 Feb 14. DOI:10.3390/pharmaceutics14020416
Olejnik A, Semba JA, Kulpa A, Dańczak-Pazdrowska A, Rybka JD, Gornowicz-Porowska J. 3D Bioprinting in Skin Related Research: Recent Achievements and Application Perspectives. ACS Synth Biol. 2022 Jan 21;11(1):26-38. DOI: 10.1021/acssynbio.1c00547.
Jiao Y, Stevic M, Buanz A, Uddin MJ, Tamburic S. Current and Prospective Applications of 3D Printing in Cosmetics: A Literature Review. Cosmetics. 2022; 9(6):115. DOI: 10.3390/cosmetics9060115.
Pasierb A, Jezierska M, Karpuk A, Czuwara J, Rudnicka L. 3D skin bioprinting: future potential for skin regeneration. Postepy Dermatol Alergol. 2022;39(5):845-851. DOI: 10.5114/ada.2021.109692.
Salama AH. Recent advances in 3D and 4D printing in pharmaceutical technology: applications, challenges, and future perspectives. Futur J Pharm Sci. 2025:11:107. DOI: 10.1186/s43094-025-00866-8
Jørgensen AK, Goyanes A, Basit AW. Entering New Domains for 3D Printing of Drug Products. Pharmaceutical Technology. 2025;49(3):24-27. https://www.pharmtech.com/view/entering-new-domains-3d-printing-drug-products
Moldenhauer D, Nguyen DCY, Jescheck L, Hack F, Fischer D, Schneeberger A. 3D screen printing – An innovative technology for large-scale manufacturing of pharmaceutical dosage forms. Int J Pharm. 2021 Jan 5;592:120096. DOI: 10.1016/j.ijpharm.2020.120096.
Liang K, Brambilla D, Leroux JC. Is 3D Printing of Pharmaceuticals a Disruptor or Enabler? Adv Mater. 2019;31(2):1805680. DOI: 10.1002/adma.201805680
Samiei N. Recent trends on applications of 3D printing technology on the design and manufacture of pharmaceutical oral formulation: A mini review. Beni-Suef Univ J Basic Appl Sci. 2020;9(1):12. DOI: 10.1186/s43088-020-00040-4.
Vaz VM, Kumar L. 3D Printing as a Promising Tool in Personalized Medicine. AAPS PharmSciTech. 2021;22(1):49. DOI: 10.1208/s12249-020-01905-8.
Lamichhane S, Bashyal S, Keum T, Noh G, Seo JE, Bastola R, Choi J, Sohn DH, Lee S. Complex formulations, simple techniques: Can 3D printing technology be the Midas touch in pharmaceutical industry? Asian J Pharm Sci. 2019;14(5):465-479. DOI: 10.1016/j.ajps.2018.11.008.
Thakkar R, Pillai AR, Zhang J, Zhang Y, Kulkarni V, Maniruzzaman M. Novel On-Demand 3-Dimensional (3-D) Printed Tablets Using Fill Density as an Effective Release-Controlling Tool. Polymers. 2020; 12(9):1872. DOI: 10.3390/polym12091872.
Zhang J, Thakkar R, Zhang Y, Maniruzzaman M. Structure-function correlation and personalized 3D printed tablets using a quality by design (QbD) approach. Int J Pharm. 2020 Nov 30;590:119945. DOI: 10.1016/j.ijpharm.2020.119945.
Ruban OA, Puliaiev DS, Khokhlenkova NV, Ivanyuk OI. The use of three-dimensional technologies in the development of oral solid dosage forms. News of Pharmacy. 2023;1(105):73-81. DOI: 10.24959/nphj.23.112
Park BJ, Choi HJ, Moon SJ, Kim SJ, Bajracharya R, Min JY, Han HK. Pharmaceutical applications of 3D printing technology: current understanding and future perspectives. J Pharm Investig. 2019;49(6):575-585. DOI: 10.1007/s40005-018-00414-y.
de Oliveira RS, Fantaus SS, Guillot AJ, Melero A, Beck RCR. 3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery. Pharmaceutics. 2021; 13(11):1946. DOI: 10.3390/pharmaceutics13111946
Sofiane B, Sofiane G. Compression performance of hollow structures: From topology optimisation to design 3D printing. Int. J. Mech. Sci. 2017, 133, 728–739. DOI: 10.1016/j.ijmecsci.2017.09.033
Zhou L, Miller J, Vezza J, Mayster M, Raffay M, Justice Q, et al. Additive Manufacturing: A Comprehensive Review. Sensors. 2024 Apr 23;24(9):2668. DOI: 10.3390/s24092668.
Matai I, Kaur G, Seyedsalehi A, McClinton A, Laurencin CT. Progress in 3D bioprinting technology for tissue/ organ regenerative engineering. Biomaterials. 2020; 226:119536. DOI:10.1016/j.biomaterials.2019.119536
Jiménez M, Romero L, Domínguez IA, Espinosa MM, Domínguez M. Additive Manufacturing Technologies: An Overview about 3D Printing Methods and Future Prospects. Complexity. 2019;9656938. DOI: 10.1155/ 2019/ 9656938
Singhvi G, Patil S, Girdhar V, Chellappan DK, Gupta G, Dua K. 3D-printing: an emerging and a revolutionary technology in pharmaceuticals. Panminerva Med. 2018; 60(4):170-173. DOI:10.23736/S0031-0808.18.03467-5
Cader HK, Rance GA, Alexander MR, et al. Water-based 3D inkjet printing of an oral pharmaceutical dosage form. Int J Pharm. 2019;564:359-368. DOI:10.1016/j.ijpharm.2019.04.026
Tabriz AG, Nandi U, Scoutaris N, et al. Personalised paediatric chewable Ibuprofen tablets fabricated using 3D micro-extrusion printing technology. Int J Pharm. 2022; 626:122135. DOI:10.1016/j.ijpharm.2022.122135
Kagita T, Guide S, Abburi SK, Devarakonda A, Maddineni S. Advancing 3D printing for personalized pediatric medicines: quality, safety, and Good Manufacturing Practice compliance. Translational and Regulatory Sciences. 2025;7(2):63-81. DOI:10.33611/trs.2025-005.
van Kampen EEM, Willemsteijn L, Ruijgrok EJ. 3D printing of drugs: expanding the options for child-tailored pharmacotherapy. Arch Dis Child. 2022;107(10):859-860. Published 2022 Sep 20. DOI:10.1136/archdischild-2021- 321629
Zheng Y, Deng F, Wang B, et al. Melt extrusion deposition (MED™) 3D printing technology - A paradigm shift in design and development of modified release drug products. Int J Pharm. 2021;602:120639. DOI:10.1016/j.ijpharm.2021.120639
Smith DM, Kapoor Y, Klinzing GR, Procopio AT. Pharmaceutical 3D printing: Design and qualification of a single step print and fill capsule. Int J Pharm. 2018;544(1):21-30. DOI:10.1016/j.ijpharm.2018.03.056
Yu CC, Shah A, Amiri N, et al. A Conformable Ultrasound Patch for Cavitation-Enhanced Transdermal Cosmeceutical Delivery. Adv Mater. 2023;35(23):e2300066. DOI:10.1002/adma.202300066
Singh G, Mohandoss K, Shah T, Dixit R, Arul V, Verma S, et al. Potential role of 3D Printing in Cosmeceuticals: Systematic Review. Afr J Bio Sc. 2024;6(10):824-853. DOI: 10.33472/AFJBS.6.10.2024.823-853
Azad MA, Olawuni D, Kimbell G, Badruddoza AZM, Hossain MS, Sultana T. Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process Perspective. Pharmaceutics. 2020; 12(2):124. DOI: 10.3390/pharmaceutics12020124
Singh S, Kumar M, Kumar D, Kumar S, Chopra S, Bhatia A. Therapeutic Precision: Unveiling the Potential of 3D Printing in Drug Delivery, Tissue Engineering, and Regenerative Medicine. 3D Print Addit Manuf. 2025;12(5): 447-473. DOI: 10.1089/3dp.2023.0364.
Kollamaram G, Croker DM, Walker GM, Goyanes A, Basit AW, Gaisford S. Low temperature fused deposition modeling (FDM) 3D printing of thermolabile drugs. Int J Pharm. 2018;545(1-2):144-152. DOI:10.1016/j.ijpharm.2018. 04.055
Goyanes A, Buanz AB, Basit AW, Gaisford S. Fused-filament 3D printing (3DP) for fabrication of tablets. Int J Pharm. 2014;476(1-2):88-92. DOI:10.1016/j.ijpharm.2014. 09.044
Jiao Y. 3D Printing in Cosmetics: Investigating New Skin Delivery Platform. Doctoral dissertation, University of the Arts London. 2024. https://ualresearchonline.arts.ac.uk/id/eprint/24117/
Aina M, Baillon F, Sescousse R, Sanchez-Ballester NM, Begu S, Soulairol I, et al. From conception to consumption: Applications of semi-solid extrusion 3D printing in oral drug delivery. Int J Pharm. 2025; 674:125436. DOI: 10.1016/j.ijpharm.2025.125436.
El Aita I, Breitkreutz J, Quodbach J. On-demand manufacturing of immediate release levetiracetam tablets using pressure-assisted microsyringe printing. Eur J Pharm Biopharm. 2019;134:29-36. DOI: 10.1016/j.ejpb.2018. 11.008.
Petrinca K, Németh Z, Csóka I, Ambrus R, Jójárt-Laczkovich O. Three-Dimensionally Printed Paediatric Medicines: Formulation, Process, and Regulatory Considerations. Pharmaceutics. 2026; 18(1):2. DOI: 10.3390/pharmaceutics 18010002.
Trenfield SJ, Madla CM, Basit AW, Gaisford S. Binder jet printing in pharmaceutical manufacturing. AAPS Adv Pharm Sci Ser. 2018;31:41-54. DOI: 10.1007/978-3-319-90755-0_3.
Fina F, Goyanes A, Gaisford S, Basit AW. Selective laser sintering (SLS) 3D printing of medicines. Int J Pharm. 2017 Aug 30;529(1-2):285-293. DOI: 10.1016/j.ijpharm.2017. 06.082.
Wang J, Goyanes A, Gaisford S, Basit AW. Stereolithographic (SLA) 3D printing of oral modified-release dosage forms. Int J Pharm. 2016 Apr 30;503(1-2):207-212. DOI: 10.1016/j.ijpharm.2016.03.016.
Cardoso PHN, Araújo ES. An Approach to 3D Printing Techniques, Polymer Materials, and Their Applications in the Production of Drug Delivery Systems. Compounds. 2024 Jan 18;4(1):71-105. DOI: 10.3390/compounds4010004.
Cai Y, Chang SY, Gan SW, Ma S, Lu WF, Yen CC. Nanocomposite bioinks for 3D bioprinting. Acta Biomater. 2022;151:45-69. DOI: 10.1016/j.actbio.2022.08.014.
Lègues M, Milet C, Forraz N, Berthelemy N, Pain S, André-Frei V, et al. The World’s First 3D Bioprinted Immune Skin Model Suitable for Screening Drugs and Ingredients for Normal and Inflamed Skin. IFSCC Magazine. 2020;(4):233-239. https://ifscc.org/wp-content/uploads/2022/03/Maxime- Legues-2022-Henry-Maso-winner.pdf
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Accepted 2026-04-08
Published 2026-04-22
