HEALING OF LINEAR CUT SKIN WOUNDS IN RATS AND ITS BIOMECHANICAL PROPERTIES UNDER THE ACTION OF MELANIN
DOI:
https://doi.org/10.11603/1811-2471.2026.v.i1.15718Keywords:
linear skin cuts, wound healing, carbopol gel with melaninAbstract
SUMMARY. The process of skin wound healing is a dynamic and complex biological process. Treatment of severe skin injuries is a serious problem worldwide. Scientists' efforts are aimed at studying natural biologically active compounds that can accelerate wound healing.
The aim – to study the effect of a pharmacological composition based on melanin and the reference Dexpanthenol+Miramistin gel on the duration of healing of linear cut skin wounds in rats and its biomechanical properties.
Material and Methods. The studies were conducted on 32 white non-linear laboratory rats, which were randomly divided into 4 groups of 8 animals each. The first group of healthy rats, in which the wounds were not simulated, constituted the intact control. The second group consisted of rats with linear cut wounds without treatment, which healed independently. In the third group of rats, linear cut wounds were treated twice a day with a pharmacological composition based on melanin (0.5% carbopol solution in which melanin was dissolved). The concentration of melanin in the carbopol solution was 0.1%. In the fourth group of rats, linear cut wounds were treated twice a day with a comparison preparation, dexpanthenol gel with miramistin.
Results. In chronic experiments on rats with experimentally induced linear incised skin wounds, daily application of a carbopol gel containing melanin was shown to accelerate healing and promote the recovery of skin strength and elasticity. These effects were reflected in improvements in key biomechanical parameters, including breaking load and relative elongation. The reference drug, Dexpanthenol+Miramistin gel, also exerted a beneficial effect on wound healing and breaking load. However, comparative analysis demonstrated that the pharmacological composition based on melanin produced a more pronounced therapeutic effect.
Conclusions. It was shown that the pharmacological composition based on melanin accelerates the healing of linear skin cuts in rats and restores its strength and elasticity, which is manifested in such biomechanical properties of the skin as the load on rupture and elongation. Dexpanthenol+Miramistin gel also had a positive effect on wound healing and lacerations. A comparison of the pharmacological composition based on melanin with the Dexpanthenol+Miramistin gel demonstrated that melanin exerted a more pronounced effect.
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