RESEARCH ON THE EFFECT OF STORAGE CONDITIONS ON THE DOSAGE OF VALERIAN TINCTURES
DOI:
https://doi.org/10.11603/1811-2471.2025.v.i4.15582Keywords:
Tinctura Valerianae, quality control, temperature, surface tension, dosageAbstract
SUMMARY. Valerian tincture is the most popular sedative over-the-counter medicine on the domestic pharmaceutical market. It is crucial for consumers to take this product at an appropriate and accurate dose. In pharmaceutical manufacturing, surface tension is the most accessible controlled parameter influencing the volume dosage of liquid medicinal forms.
The aim – to evaluate the influence of storage conditions on the dosage regimen of Valerian tinctures.
Material and Methods. Valerian tincture samples (Tinctura Valerianae) produced by PJSC Pharmaceutical Factory "Viola" (Zaporizhzhia) and LLC "Ternopharm" (Ternopil) were used for the research. The mass of tincture drops was determined by measuring their surface tension using the stalagmometric method (counting falling drops). Measurements were carried out within a temperature range of 2-25 °C. The results were analyzed using statistical methods and the method of correlation analysis.
Results. With increasing temperature, the surface tension of the Valerian tincture samples decreases linearly, with a low angular coefficient. The correlation between the surface tension of the tinctures and the mass of their droplets at different temperatures makes it possible to estimate the effect of temperature on the dosage of the liquid dosage form. Deviations in the preparations’ drop mass under changing storage conditions were found to be insignificant. This confirmed that the storage temperature regime of the investigated tincture samples from 2 to 25 °C is reasonable.
Conclusions. The temperature dependences of the surface tension of Valerian tincture samples with high correlation coefficients were established. The masses of tincture droplets were determined for the extreme storage temperature limits: 2 and 25 °C (as per the instructions for medical use of medicinal products). It was shown that the storage temperature of tinctures practically does not affect the dosage of drops. Thus, the surface tension of liquid dosage forms is an important parameter for assessing their quality.
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