ANALYSIS OF MORPHO-FUNCTIONAL CHANGES IN THE HEART, LUNGS, AND KIDNEYS UNDER CONDITIONS OF EXPERIMENTAL CHRONIC ALCOHOL INTOXICATION AND ITS CORRECTION WITH THIOTRIAZOLINE
DOI:
https://doi.org/10.11603/1811-2471.2025.v.i1.15257Keywords:
thiotriazoline, alcohol, heart, lung, kidney, morphology, experimentAbstract
SUMMARY. Alcohol abuse and the consequences of this addiction have negative medical effects and social implications that deteriorate quality of life. The development of alcohol liver disease, cardiomyopathy, encephalopathy, and nephropathy play significant roles for negative prognosis. Multiple organ damage requires organ-protective drugs that target several organs simultaneously. Therefore, studying the structural manifestations of the therapeutic effects of medications is a fundamental criterion for effectiveness evidence and avoiding polypharmacy.
The aim – to determine the morphological evidence of the effectiveness of thiotriazoline in the structural recovery of the heart, lungs, and kidneys after the experimental chronic alcoholic intoxication.
Material and Methods. A histological study was conducted on 12 laboratory rats, which were subjected to ethanol-induced organ damage. There were two groups with 6 rats in each group. All rats were administered 40% ethanol solution orally four times a day for 2 weeks. Ethanol intoxication correction was made with 100 mg/kg body weight of thiotriazoline for 14 days.
Results. Chronic alcohol intoxication caused degeneration, atrophy and necrosis of cardiomyocytes, hemodynamic disturbances and inflammatory process in myocardium. Changes in the lung tissue and bronchial wall manifested as interstitial pneumonia and bronchopneumonia. Histological examination of the kidneys revealed blood-filled and collapsed glomeruli, dystrophy and necrosis of tubular epithelial cells, desquamated cells in the tubules, edema, and inflammatory infiltration. Under the influence of thiotriazoline, partial structural recovery was noted mostly in expression of stromal edema, dystrophic changes, as well as a decrease in the volume of necrosis and inflammation.
Conclusions. Chronic alcohol intoxication caused morphological changes in the organs, manifested as dystrophic and necrotic signs and inflammation. The morphofunctional recovery of the heart under the influence of thiotriazoline was more pronounced than that of the lungs and kidneys due to varying degrees of reduction in morphological changes.
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