CLINICAL AND BIOCHEMICAL CHARACTERISTICS OF OSTEOARTHRITIS ON THE BACKGROUND OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
DOI:
https://doi.org/10.11603/1811-2471.2025.v.i1.15245Keywords:
osteoarthritis, chronic obstructive pulmonary disease, lungs, pain, tumor necrosis factor α, С- reactive proteinAbstract
SUMMARY. Osteoarthritis (OA) is an important social, economic and medical problem, prone to a chronic course and often becomes the cause of early disability of patients. An imbalance of the immune system plays an important role in the development and the course of chronic diseases, in particular OA and chronic obstructive pulmonary disease (COPD).
The aim – to study the features of the clinical and biochemical manifestations of OA in combination with COPD.
Material and Methods. 53 patients with OA (group I) and 25 patients with OA combined with COPD (group II) were examined. The control group was 20 healthy people. OA was diagnosed based on the criteria of the American College of Rheumatology and approved by the Association of Rheumatologists of Ukraine. The diagnosis of COPD was verified based on the clinical picture and instrumental data according to the Order of the Ministry of Health of Ukraine dated June 27, 2013 No. 555. The severity of the joint syndrome was assessed by the following indicators: joint index (JI), pain index (PI), Lequen algofunctional index (AIL), pain on the visual analogue scale (VAS). Immunological study included determination of C-reactive protein (C-RP) and Tumor necrosis factor α (TNF-α) in blood serum on a photometer – enzyme immunoassay analyzer “Sunrise” (Austria). Statistical processing of the results was performed using the Microsoft Office Excel 2016 statistical functions package (Microsoft Corp., USA) with determination of the Student test (t) and statistical significance (p).
Results. OA combined with COPD has a more severe clinical course than OA without concomitant pathology. For examples, such patients more often complained about limitation of active movements, a feeling of rapid fatigue in the legs, and lameness compared to persons suffering from only OA. In OA-COPD group patients had more pronounced growth of JI, more intense pain according to VAS during active movements than in patients without concomitant COPD. In persons with mixed pathology we established statistically reliable increase of the intensity of the inflammatory process according to the concentration of C-RP and TNF-α compared to patients without concomitant pathology.
Conclusions. The worsening of the clinical course of OA on the background of COPD is manifested by a probable increase in the intensity of the joint syndrome (JI, AIL, pain intensity according to VAS and PI during active movements), an increase in inflammation indicators (C-RP, TNF-α) compared to patients with OA alone.
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