SMALL INTESTINAL BACTERIAL OVERGROWTH SYNDROME MANAGEMENT IN PATIENTS WITH DYSLIPIDEMIA: NEW POSSIBILITIES
DOI:
https://doi.org/10.11603/1811-2471.2024.v.i4.14981Keywords:
dyslipidemia, SIBO, microbiome, hypercholesterolemiaAbstract
SUMMARY. Small intestinal bacterial overgrowth (SIBO) syndrome is a condition associated with digestive disorders and metabolic disturbances, linked to increased cardiovascular disease risk in patients with dyslipidemia. SIBO may disrupt lipid metabolism by affecting gut microbiota.
The aim – to determine the prevalence of SIBO in patients with dyslipidemia and assess the impact of SIBO treatment on correcting lipid metabolism.
Material and Methods. The study involved 342 dyslipidemic patients who underwent a hydrogen breath test to diagnose SIBO. Clinical, biochemical, and instrumental examinations, including breath hydrogen test for SIBO determination, with statistical analysis, were conducted.
Results. SIBO was diagnosed in 45.2 % of patients with dyslipidemia. Combined therapy with rifaximin and Saccharomyces Boulardii CNCM I-745 reduced clinical symptoms in 38–56 % of patients and improved the lipid profile, lowering levels of total cholesterol, triglycerides, and LDL.
Conclusion. SIBO treatment in patients with dyslipidemia may serve as an essential component in lipid metabolism correction, reducing cardiovascular risk. The positive effect of combined therapy on symptomatology and lipidogram underscores the value of SIBO therapy in dyslipidemia management.
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