STUDY OF THE PROSTATE PROTECTIVE EFFECT OF THICK EXTRACT FROM MAITAKE MUSHROOMS ON THE MODEL OF TESTOSTERONE-INDUCED PROSTATIC HYPERPLASIA
DOI:
https://doi.org/10.11603/1811-2471.2023.v.i3.14078Keywords:
maitake mushrooms, thick extract, prostatic hyperplasia, prostate protective action, antioxidant effectAbstract
SUMMARY. Adenoma of the prostate gland ranks first among male urological diseases. It leads to a significant deterioration of the quality of life of men due to disorders of the genitourinary system and reproductive function, and the psycho-emotional state is also disturbed. Although various therapeutic measures are used to treat prostatitis, the effectiveness of treatment remains at a low level. Therefore, the search and creation of new drugs from the group of prostate protectors is urgent.
The aim – to study experimentally the prostatoprotective properties of a thick extract from maitake mushrooms under the conditions of testosterone-induced benign prostatic hyperplasia in white rats.
Мaterial and Methods. Prostate adenoma was modeled by subcutaneous injection of testosterone propionate solution at a dose of 3 mg/kg to male white rats for 21 days. A thick extract of maitake mushrooms was administered intragastrically to test animals daily at a dose of 150 mg/kg of rat body weight simultaneously with subcutaneous administration of testosterone propionate for 3 weeks. The comparison drug "Prostatofit" in a dilution of 1:10 at a dose of 1 ml/100 g of the animal's body weight was administered intragastrically according to the same scheme as the maitake mushroom extract. Homogenate of the prostate and blood serum of rats were taken for laboratory research. The prostatoprotective effect of the extract from maitake mushrooms was evaluated by the activity of acid and alkaline phosphatase, the content of TBA-active products and reduced glutathione, the phosphatase index (AP/ALP) was calculated.
Results. Administration of testosterone propionate to white male rats for 21 days likely disrupts the activity of phosphatases, leads to an increase in TBC-active products and a decrease in the content of reduced glutathione in blood serum and prostate homogenate of affected animals. The effectiveness of the use of a thick extract from maitake mushrooms under the conditions of testosterone-induced benign prostatic hyperplasia in rats has been proven. The studied extract suppresses lipid peroxidation and normalizes the antioxidant/prooxidant balance in the body of animals with pathology.
Conclusions. A thick extract from maitake mushrooms under the conditions of simulated hyperplasia of the prostate gland reliably exhibits a prostatoprotective effect. The obtained results of research on the antioxidant effect of the studied extract, since maitake mushrooms contain steroid compounds, phenols, flavonoids and vitamins.
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