ONCOSIS, APOPTOSIS AND AUTOPHAGY OF CARDIAC MYOCIES IN CARDIOMYOPATHIES OF DIFFERENT AETIOLOGIES: MORPHOLOGICAL DIFFERENTIATION
DOI:
https://doi.org/10.11603/1811-2471.2023.v.i1.13616Keywords:
cardiomyopathy, cell death, oncosis, apoptosis, autophagy, morphologyAbstract
SUMMARY. It is known that cardiomyocytes have a limited ability to regenerate, their excessive death by oncosis, apoptosis or autophagy leads to unfavorable remodeling of the heart.
The aim – to analyze modern research on this issue.
Results. The review analyzes modern research in the direction of cell death of cardiac myocytes in cardiomyopathies of various etiologies, describes in detail the morphological characteristics of oncosis, apoptosis, and autophagy at the cellular and subcellular levels.
Conclusions. With the use of bibliographic and analytical methods, a comparative table was created, where differential criteria and signs characteristic of the types of cell death of cardiomyocytes considered in the article are highlighted.
References
Whelan, R.S., Kaplinskiy, V., & Kitsis, R.N. (2010). Cell death in the pathogenesis of heart disease: mechanisms and significance. Annu Rev. Physiol., 72, 19-44. DOI: https://doi.org/10.1146/annurev.physiol.010908.163111
Orogo, A.M., & Gustafsson, A.B. (2013). Cell death in the myocardium: my heart won’t go on. IUBMB Life, 5(8), 651-656. DOI: https://doi.org/10.1002/iub.1180
Mishra, P.K., Adameova A., Hill, J.A., Baines, C.P., Kang, P.M., & Downey, J.M. (2019). Guidelines for evaluating myocardial cell death. Am. J. Physiol. - Hear Circ. Physiol., 317(5), H891-922. DOI: https://doi.org/10.1152/ajpheart.00259.2019
Grasl-Kraupp, B., Ruttkay-Nedecky, B., Koudelka, H., Bukowska, K., Bursch, W., & Schulte-Hermann, R. (1995). In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note. Hepatology, 21(5),1465-1468. DOI: https://doi.org/10.1002/hep.1840210534
Buja, L.M., & Entman, M.L. (1998). Modes of myocardial cell injury and cell death in ischemic heart disease. Circulation. United States, 98, 1355-1357. DOI: https://doi.org/10.1161/01.CIR.98.14.1355
Freude, B., Masters, T.N., Kostin, S., Robicsek, F., & Schaper, J. (1998). Cardiomyocyte apoptosis in acute and chronic conditions. Basic Res. Cardiol., 93(2), 85-89. DOI: https://doi.org/10.1007/s003950050066
Buja, L.M., & Vela, D. (2008). Cardiomyocyte death and renewal in the normal and diseased heart. Cardiovasc. Pathol., 17(6), 349-374. DOI: https://doi.org/10.1016/j.carpath.2008.02.004
Ohno, M., Takemura, G., Ohno, A., Misao, J., Hayakawa, Y., & Minatoguchi, S. (1998). “Apoptotic” myocytes in infarct area in rabbit hearts may be oncotic myocytes with DNA fragmentation analysis by immunogold electron microscopy combined with in situ nick end-labeling. Circulation, 98(14), 1422-430. DOI: https://doi.org/10.1161/01.CIR.98.14.1422
Saraste, A. (1999). Morphologic criteria and detection of apoptosis. Herz, 24(3), 189-195. DOI: https://doi.org/10.1007/BF03044961
Majno, G., & Joris, I. (1995). Apoptosis, oncosis, and necrosis. An overview of cell death. Am. J. Pathol., 146(1), 3-15.
Tumanovska, L.V., Dosenko, V.I., Nahibin V.S., Makohon N. V., & Moibenko O.O. (2004). Apoptotic, autophagic, and oncotic death of cardiomyocytes in anoxia-reoxygenation. Fiziol. Zh., 50(5), 11-18.
Takemura, G., Kato, S., Aoyama, T., Hayakawa, Y., Kanoh, M., & Maruyama, R. (2001). Characterization of ultrastructure and its relation with DNA fragmentation in Fas-induced apoptosis of cultured cardiac myocytes. J. Pathol., 193(4), 546-556. DOI: https://doi.org/10.1002/1096-9896(2000)9999:9999<::AID-PATH794>3.0.CO;2-L
Samejima, K., Toné, S., Kottke, T.J., Enari M., Sakahira H., & Cooke C.A. (1998). Transition from caspase-dependent to caspase-independent mechanisms at the onset of apoptotic execution. J. Cell Biol., 143(1), 225-239. DOI: https://doi.org/10.1083/jcb.143.1.225
Balvan, J., Krizova, A., Gumulec, J., Raudenska, M., Sladek, Z., & Sedlackova, M. (2015). Multimodal holographic microscopy: Distinction between apoptosis and oncosis. PLoS One., 10(3), 1-16. DOI: https://doi.org/10.1371/journal.pone.0121674
Schaper, J., Kostin, S., Hein, S., Elsässer, A., Arnon, E., & Zimmermann, R. (2002). Structural remodelling in heart failure. Exp. Clin. Cardiol., 7(2-3), 64-68.
Devaux, B., Scholz, D., Hirche, A., Klövekorn, W.P., & Schaper, J. (1997). Upregulation of cell adhesion molecules and the presence of low grade inflammation in human chronic heart failure. Eur. Heart J., 18(3),470-479. DOI: https://doi.org/10.1093/oxfordjournals.eurheartj.a015268
Kostin, S., Pool, L., Elsässer, A., Hein, S., Drexler, H.C.A., & Arnon, E. (2003). Myocytes die by multiple mechanisms in failing human hearts. Circ. Res., 92(7), 715-724. DOI: https://doi.org/10.1161/01.RES.0000067471.95890.5C
Lavandero, S., Troncoso, R., Rothermel, B.A., Martinet, W., Sadoshima, J., & Hill, J.A. (2013). Cardiovascular autophagy: concepts, controversies, and perspectives. Autophagy, 9(10),1455-1466. DOI: https://doi.org/10.4161/auto.25969
Lavandero, S., Chiong, M., Rothermel, B.A., & Hill, J.A. (2015). Autophagy in cardiovascular biology. J. Clin. Invest., 125(1), 55-64. DOI: https://doi.org/10.1172/JCI73943
Gatica, D., Chiong, M., Lavandero, S., & Klionsky, D.J. (2022). The role of autophagy in cardiovascular pathology. Cardiovasc. Res.,118(4), 934-950. DOI: https://doi.org/10.1093/cvr/cvab158
Kari, S., Subramanian, K., Altomonte, I.A., Murugesan, A., Yli-Harja, O., & Kandhavelu, M. (2022). Programmed cell death detection methods: a systematic review and a categorical comparison. Apoptosis [Internet], 27(7-8), 482-508. DOI: 10.1007/s10495-022-01735-y. DOI: https://doi.org/10.1007/s10495-022-01735-y
Corsetti, G., Chen-Scarabelli, C., Romano, C., Pasini, E., Dioguardi, F.S., & Onorati, F. (2019). Autophagy and Oncosis/Necroptosis Are Enhanced in Cardiomyocytes from Heart Failure Patients. Med. Sci. Monit. Basic Res., 25, 33-44. DOI: https://doi.org/10.12659/MSMBR.913436
Gatica, D., Chiong, M., Lavandero, S., & Klionsky, D.J. (2015). Molecular mechanisms of autophagy in the cardiovascular system. Circ. Res., 116(3), 456-467. DOI: https://doi.org/10.1161/CIRCRESAHA.114.303788
Doran, J.P., Howie, A.J., Townend, J.N., & Bonser, R.S. (1996). Detection of myocardial infarction by immunohistological staining for C9 on formalin fixed, paraffin wax embedded sections. J. Clin. Pathol., 49(1), 34-37. DOI: https://doi.org/10.1136/jcp.49.1.34
Goswami, S.K., & Das, D.K. (2006). Autophagy in the myocardium: Dying for survival? Exp. Clin. Cardiol., 11(3), 183-188.
Edinger, A.L., & Thompson, C.B. (2004). Death by design: apoptosis, necrosis and autophagy. Curr. Opin. Cell Biol., 16(6), 663-669. DOI: https://doi.org/10.1016/j.ceb.2004.09.011
Zhang, J., Liu, D., Zhang, M., & Zhang, Y. (2019). Programmed necrosis in cardiomyocytes: mitochondria, death receptors and beyond. Br. J. Pharmacol., 176(22), 4319-4339. DOI: https://doi.org/10.1111/bph.14363
Trump, B.F., Berezesky, I.K., Chang, S.H., & Phelps, P.C. (1997). The pathways of cell death: oncosis, apoptosis, and necrosis. Toxicol. Pathol., 25(1), 82-88. DOI: https://doi.org/10.1177/019262339702500116
Weerasinghe, P., & Buja, L.M. (2012). Oncosis: an important non-apoptotic mode of cell death. Exp. Mol. Pathol., 93(3), 302-308. DOI: https://doi.org/10.1016/j.yexmp.2012.09.018
Maruyama, R., Takemura, G., Aoyama, T., Hayakawa, K., Koda, M., & Kawase, Y. (2001). Dynamic process of apoptosis in adult rat cardiomyocytes analyzed using 48-hour videomicroscopy and electron microscopy: Beating and rate are associated with the apoptotic process. Am. J. Pathol., 159(2), 683-691. DOI: https://doi.org/10.1016/S0002-9440(10)61739-7
Abbate, A., De Falco, M., Morales, C., Gelpi, R.J., Prisco, M., & De Luca, A. (2007). Electron microscopy characterization of cardiomyocyte apoptosis in ischemic heart disease. Int. J. Cardiol., 114(1),118-120. DOI: https://doi.org/10.1016/j.ijcard.2005.11.025
Arbustini, E., Brega, A., & Narula, J. (2008). Ultrastructural definition of apoptosis in heart failure. Heart Fail. Rev., 13(2), 121-135. DOI: https://doi.org/10.1007/s10741-007-9072-8
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Achievements of Clinical and Experimental Medicine
This work is licensed under a Creative Commons Attribution 4.0 International License.
