COLON DYSBIOSIS IN PATIENTS WITH COLORECTAL CANCER

Abstract

SUMMARY. The article presents the conclusions of bacteriological studies of colon feces in patients with colorectal cancer, which were performed on the basis of the Transcarpathian Antitumor Center. Changes in intestinal microbiota were found in almost all studied patients. The formation of dysbiosis of the large intestine in patients with CRC can be explained by the breakdown of adaptive, protective, compensatory mechanisms, in which the macroorganism does not have time to produce effective protective mechanisms against toxic substrates, resulting in dysbiotic disturbances of the intestine of varying degrees of severity.

This fact worsens the course of the main disease and the quality of life of patients. Changes in the quantitative and qualitative composition of the microflora of the colon require correction: an increase in the number of bifido- and lactobacteria and a decrease in the number of opportunistic bacteria, so each patient should have an individual treatment scheme for dysbiotic phenomena in the intestines.

The aim – to assess the quantitative and qualitative state of the microflora of the large intestine. To study changes in indicators of the degree of dysbiosis of the large intestine in different stages of the tumor process in patients with CRC.

Material and Methods. We observed 75 patients with a verified diagnosis of CRC who were being treated at the communal non-profit enterprise "Transcarpathian Antitumor Center" for the period 2018–2021. The patients were divided according to the stages of the pathological process as follows: 6 patients had I stage in 14 patients was stage II, in 34 – stage III, in 21 – stage IV of the tumor process. In all cases, the diagnosis was made with the help of bacteriological examination of feces.

Results and Discussion. Self-observation of 75 patients with a diagnosis of CRC was carried out, of which dysbiosis of the large intestine was found in 72 patients. In the majority of patients with CRC, permanent pathological changes in the microecology of the colon were found, which were characterized by a change in the total number of typical E. coli, the appearance of hemolytic E. coli, a deficiency of the main representatives of the microbial landscape – bifidobacteria and lactobacteria, and an increase in the number of putrefactive and fungal bacteria. In such patients, suppression of all indicators of immunity is often noted. As you know, there is a close connection between the state of immunity and candidiasis. Candidiasis can be both a consequence and a cause of immune deficiency, which contributes to the generalization of candidal infection. The above data give reason to claim that the use of immunocorrectors, as well as antifungal agents, is mandatory in the correction of dysbiotic disorders in this category of patients. That is why, in our opinion, it is not important which of them came first – dysbiotic changes of the colon or tumor intoxication, and the need to correct dysbiosis of the colon.

Conclusions. To increase the effectiveness of treatment of patients with CRC, it makes sense to conduct a bacteriological analysis of feces and correct dysbiosis with microbial complexes, while each patient should have an individual approach.