THE DYNAMICS OF ENDOGENOUS INTOXICATION PARAMETERS IN PERIOD OF LATE MANIFESTATIONS OF CRANIOSKELETAL TRAUMA IN CASE OF CONCOMITANT CHRONIC HEPATITIS AND EFFECTIVENESS OF CORRECTION WITH ARMADINE
DOI:
https://doi.org/10.11603/1811-2471.2022.v.i2.13141Keywords:
cranioskeletal trauma, chronic hepatitis, endotoxicosis, armadineAbstract
SUMMARY. Chronic liver disease today is a very common pathology. On the background of increasing injuries, the risk of injury to people with concomitant diffuse liver damage increases significantly. A common mechanism of pathogenesis of these pathological processes is the development of endogenous intoxication syndrome.
The aim – to determine the dynamics of markers of endogenous intoxication in the period of late manifestations of cranioskeletal trauma in the conditions of concomitant chronic hepatitis and to evaluate the effectiveness of armadine correction.
Material and Methods. Cranioskeletal trauma, chronic hepatitis, and its combinations were modelled in separate groups of nonlinear white male rats. Armadine at a dose of 20 mg/kg intraperitoneally was used to treat the group with combined lesions. After 14, 21, 28 and 35 days after injury, the content of fractions of molecules of average mass determined at the wavelength of 238, 254, 260 and 280 nm was determined in the serum of experimental animals.
Results. Simulation of cranioskeletal trauma in the period of late manifestations of traumatic disease is accompanied by increased endogenous intoxication, which is manifested by a significant increase in the content in the serum of the studied fractions of molecules. Parameters after 14 days of the post-traumatic period significantly exceed the level of control, but up to 21 days increase even more with a subsequent decrease to 35 days, which reaches control. After modelling of the injury on the background of chronic hepatitis in all periods of the late manifestations of traumatic disease, the content of the studied fractions of molecules of medium weight is statistically significantly higher than in injured animals without chronic liver disease. In the dynamics, most indicators also reach a maximum after 21 days and then decrease, but do not reach the level of control. Due to the use of armadine in rats with cranioskeletal trauma and chronic hepatitis compared with animals without treatment from 21 days of the experiment show a statistically significant decrease in fractions of 238 and 260 nm. After 28 and 35 days, the value of all studied parameters becomes significantly smaller than in animals without correction. Consequently, armadine is able to reduce the manifestations of endogenous intoxication syndrome, caused by both pathogenic mechanisms of chronic hepatitis and cranioskeletal trauma.
Conclusions. Application of cranioskeletal trauma on the background of chronic hepatitis in the late manifestations of traumatic disease compared to animals without concomitant liver damage causes increased endotoxicosis, which is manifested by increased serum fractions of molecules of average weight 238, 254, 260 and 280 nm. The use of armadine in this group of animals compared with animals without correction significantly reduces the level of markers and the level of endogenous intoxication after 28 and 35 days of the post-traumatic period.
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