STRUCTURE OF ORTHOPHRAL MICROBIOM AND ANTIBIOTICS RESISTANCE OF INDIVIDUAL REPRESENTATIVES IN PATIENTS WITH DIABETES IN SUGAR DIABAMATABATE

Abstract

SUMMARY. Diabetes mellitus (DM) is the most common endocrine disease in the world. According to the WHO, the number of patients reaches 420 million. The influence of the oropharyngeal microbiome on the quality of life of patients with diabetes is extremely important, as acute respiratory diseases (ARI) are most often caused by normoflora. Therefore, for effective treatment of ARI it is necessary to determine the antibiotic resistance of the microbiome of patients with diabetes.

The aim – to determine the composition of the oropharyngeal microbiome in 25 patients with type II diabetes and antibiotic resistance of isolated streptococci to the most common antibiotics.

Material and Methods. bacteriological examination of oropharyngeal swabs and determination of antibiotic resistance isolated from patients with diabetes of streptococci by the Kirby-Bauer method; statistical analysis of the obtained data.

Results. According to statistical analysis, patients with diabetes in the outpatient stage of ARI take antibiotics, the leading among which is azithromycin 11 (44.0 %), which is a representative of a new group of macrolide antibiotics.

According to the results of bacteriological research and analysis of the persistence index (C) and the meeting index (Pi), the leading place in the structure of the oropharyngeal microbiome is occupied by streptococci, in particular β-hemolytic, which were sown from patients with diabetes in 64% of cases.

Streptococci isolated from the oral pharynx of patients with diabetes are the most sensitive to ceftriaxone – 18 (64.29 %) in second place in sensitivity to amoxacillin and chloramphenicol 15 (53.60 %), and only every 4-th strain was sensitive to azithromycin, The number of azithromycin-resistant strains was in second place: ceftazidime – 19 (67.86 %), azithromycin – 13 (46.43 %).

Conclusions. Patients with diabetes should be examined for oropharyngeal microbiome and antibiotic susceptibility of isolated microorganisms in order to rationally treat antibiotic episodes of ARI and prevent the spread of antibiotic-resistant strains.