RECENT VIEWS ON MORPHOLOGICAL DIAGNOSTICS OF THE MOST COMMON CARDIOVASCULAR COMPLICATIONS OF COVID-19 ACCORDING TO THE LITERATURE REVIEWS AND OWN HISTOLOGICAL EXAMINATIONS
DOI:
https://doi.org/10.11603/1811-2471.2021.v.i2.12207Keywords:
COVID-19, endotheliitis, myocardial infarction, myocarditisAbstract
The study of pathogenic impact of SARS-COV-2 on the respiratory and cardiovascular systems of the human body is consequential, as diseases of the heart and coronary blood vessels are the cause of numerous lethal cases and development of complications that noticeably aggravate the quality of patient’s life.
The aim – to investigate of pathogenic and morphological peculiarities of the main cardiovascular complications of COVID-19.
Material and Methods. Conducted the analysis of scientific literature and investigated hearts of 4 patients who died from the cardiovascular insufficiency in the hospitals of Ternopil region with laboratory verified coronavirus infection.
Results. Demonstrated that cardiovascular complications of COVID-19 are related with the endothelium damage, hypercoagulation (pulmonary artery embolism, myocardial infarction, stroke) and systemic inflammation (myocarditis).
Conclusions. The reasons of the development of acute cardiovascular failure in patients with COVID-19 are alternative inflammatory changes of the myocardial parenchymal component, hypercoagulation and blood vessels endothelium damage.
References
Tian, S., Xiong, Y., Liu, H., Niu, L., Guo, J., Liao, M., & Xiao, S.-Y. (2020). Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies. Mod. Pathol., 33 (6), 1007-1014. DOI: 10.1038/s41379-020-0536-x
Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., & Pöhlmann S. (2020). SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell, 181 (2), 271-280.e8. DOI: 10.1016/j.cell.2020.02.052
Sakai, K., Ami, Y., Tahara, M., Kubota, T., Anraku, M., Abe, M., & Takeda, M. (2014). The host protease TMPRSS2 plays a major role in in vivo replication of emerging H7N9 and seasonal influenza viruses. J. Virol., 88 (10), 5608-5616. DOI: https://doi.org/10.1128/JVI.03677-13
Yermolenko, A.S., Lisova, Ye.M., Sharun, S.N., & Bocharova, T.V. (2020). Analiz vplyvu koronavirusnoi infektsii na sertse [Analysis of the effect of coronavirus infection on the heart]. Wissenschaftliche Ergebnisse und Errungenschaften, 2, 43-44. DOI:10.36074/25.12.2020.v2.11
Komisarenko, S.V. (2020). Poliuvannia vchenykh na koronavirus SARS-COV-2, shcho vyklykaie COVID-19: naukovi stratehii podolannia pandemii [Hunting of scientists for coronavirus SARS-COV-2, which causes COVID-19: scientific strategies for overcoming the pandemic]. Visn. NAN Ukrainy – NAS Ukraine Bulletin, 8, 29-71 [in Ukrainian].
Oryshchyn, N., & Ivaniv, Yu. (2020). Sertsevo-sudynni uskladnennia u patsiientiv iz COVID-19: opys klinichnoho vypadku ta ohliad literatury [Cardiovascular complications in patients with COVID-19: description of the clinical case and review of the literature]. Pratsi NTSH Medychni nauky – Proceedings of the NTSh Medical Sciences, 2 (62), 87-98. DOI: 10.25040/ntsh2020.02.08
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