MORPHOMETRIC STUDY OF ARTERIES OF THE LOWER JAW REORGANIZATION ASPECTS IN THE SIMULATED POST-RESECTION ARTERIAL PULMONARY HYPERTENSION

Abstract

Summary. The salivary glands are a special group of secretory organs that play a significant role in dental health of the population, as well as one of the vital functions of the whole human body. With the development of modern medical science, clinicians have often diagnosed salivary gland pathology. One of the most important problems of these pathologies is the study of direct and reverse effects of organs on each other, the principles of their correlations and methods of morphological expression. In recent decades, there has also been an increase of pulmonary lesions, which are accompanied by hypertension in the small circulation and lead to the development of pulmonary heart disease and its decompensation. There are isolated studies on the features of the involvement of the mandibular gland in the pathological process, and only some works reflect the structural changes of the submandibular gland in hemodynamic disorders.

The aim of the work – to study morphometric aspects of mandibular arteries reorganization in simulated post-resection arterial pulmonary hypertension.

Material and Methods. The arteries of medium (51–125) μm and small (26–50) μm calibers [16] of the mandibular salivary gland of 27 Vietnamese pigs, which were divided into 3 groups, were studied by a complex of histological and morphometric methods. Group 1 included 9 intact animals aged 6.5–7 months, group 2 – 12 pigs of the same age with post-resection pulmonary hypertension and compensated pulmonary heart, group 3 – 6 animals 6.5–7 months with pulmonary hypertension and decompensated pulmonary heart.

Results and Discussion. Hypertension (one-month term) in the small circle of blood circulation, which occurred after right-sided pulmonectomy led to the development of pulmonary heart and venous stasis in the organs of the large circle of blood circulation, including in the mandibular gland. At arterial hypertension in a small circle of blood circulation essential structural reorganization of arteries of a mandibular gland is revealed. Although morphological changes were found in the arteries of small caliber of the studied organ and in the decompensation of the pulmonary heart.

Conclusions. Our morphological study provided comprehensive information on the features of remodeling of the mandibular arteries in postresection arterial pulmonary hypertension. Prolonged pulmonary hypertension leads to structural rearrangement of the arteries of the middle and small caliber of the mandible, which is characterized by thickening of the membrane, narrowing their lumen and endothelial cells damage, impaired blood supply and hypoxia in the body. The biggest changes are in the arteries of the small caliber of the mandibular gland and in the decompensation of the pulmonary heart in 6.5–7 month old male pigs of the Vietnamese breed.