MORPHOLOGICAL CHANGES IN THE CAPACITIVE LINK OF THE HEMOMICROCIRCULATORY BED OF LUNG OF GUINEA PIGS SENSITIZED WITH OVALBUMIN
DOI:
https://doi.org/10.11603/1811-2471.2021.v.i1.11691Keywords:
venule, microcirculation, experimental allergic inflammation, lung, ovalbumin, guinea pigAbstract
An urgent issue in medicine today is the reaction of lungs microvessels with chronic respiratory allergic diseases, because the full functioning of tissues and cells depends on the microvessels.
The aim – to study the morphological changes in the vessels of the capacitive link of the microcirculatory bed of the lung of guinea pigs sensitized with ovalbumin.
Material and Methods. We have studied the lung of 48 guinea pigs, using histological and morphometric methods, under conditions of experimental ovalbumin-induced allergic inflammation, simulated by three times subcutaneous sensitization and subsequent 8-day intranasal inhalation of ovalbumin. To assess the structural and functional state of postcapillary and muscular venules the inner diameter of the vessels was determined.
Results. A general regularity of the reactivity of the capacitive link of the hemomicrocirculatory bed of guinea pig lungs in experimental ovalbumin-induced allergic inflammation was established, consisted in the restructuring of postcapillary and muscle venules such as an increase in the diameter of their lumen and the permeability of their wall. More pronounced morphological changes were found in postcapillary venules in the early period of allergic inflammation, confirmed with the magnification factor, showed increase in the diameter of the lumen of postcapillary venules (1.7) in the first experimental group compared to the control.
Conclusions. Sensitization and inhalation allergization with ovalbumin leads to structural reorganization-vasodilation of the postcapillary and muscle venules of guinea pigs lungs, depended on the diameter of the vessels and the experiment duration and is a manifestation of a violation of the recovery and adaptation processes of microcirculation. The most pronounced changes appear during the early period of allergic inflammation in the postcapillary venules.
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