CHANGES IN TROPHOLOGICAL STATUS IN PATIENTS WITH CHRONIC PANCREATITIS AND DIABETES MELLITUS
DOI:
https://doi.org/10.11603/1811-2471.2020.v.i2.11336Keywords:
chronic pancreatitis, diabetes mellitus, trophological statusAbstract
The pancreas (P) produces more than 20 digestive enzymes per day. In diseases of the pancreas, this functional activity is reduced, resulting in digestive disorders with the development of trophological insufficiency.
The aim – to determine the features of trophological status in patients with chronic pancreatitis (CP) and diabetes mellitus (DM) types 1 and 2.
Material and Methods. 126 patients with CP and diabetes were examined. Patients with CP were divided into 2 groups: the first group included 62 patients with type 1 diabetes, and the second group consisted of 64 patients with type 2 diabetes. All examined patients underwent general clinical studies, as well as bioimpedancemetry.
Results and Discussion. Among patients of group I, there is a prevalation of patients with normal body weight and body weight deficit (42.0 % and 29.0 % – p <0.01), while among patients with CP and type 2 diabetes – obese people of the first degree and overweight (31.2 % (p <0.01) and 28.1 % (p <0.05)). Group I patients had a deficiency of muscle and bone mass, as well as a lack of fluid in the body, while patients of group II were diagnosed with a pronounced accumulation of fat in the body and a decrease in muscle mass, as well as fluid overload.
Conclusions. Anthropometric studies indicate a predominance of patients with weight loss and normal weight in the group of patients with CP and type 1 diabetes, while among patients with CP and type 2 diabetes is dominated by obese I degree and overweight. In patients with CP and diabetes mellitus type 1 study of body composition indicates a deficiency of muscle and bone mass, as well as a relative decrease in fluid content, while in patients of group II (combination of CP and type 2 diabetes) was diagnosed with an increase in fat mass and fluid component tendencies to decrease muscle mass.
References
Raksha, N.H., Halenova, T.I., & Vovk, T.B. (2019). Proteolitychnyi dysbalans yak faktor rozvytku khronichnoho pankreatytu okremo ta za naiavnosti tsukrovoho diabetu 1 typu [Proteolytic imbalance as a factor in the development of chronic pancreatitis separately and in the presence of type 1 diabetes]. Klinichna ta eksperymentalna medytsyna – Clinical and Experimental Medicine, 3 (152), 186-191 [in Ukrainian].
Khrystych, T.M., & Hontsaryuk, D.O. (2018). Etiolohichni faktory, shcho formuiut khronichnyi pankreatyt [Etiological factors that form chronic pancreatitis]. Zdobutky klinichnoi ta eksperymentalnoi medytsyny – Achievements of Clinical and Experimental Medicine, 3, 20-27 [in Ukrainian].
Laryn, A.S., & Tkach, S.M. (2016). Patogeneticheskaya rol kyshechnogo disbioza v razvitii ozhyreniya, insulinorezistentnosti i sakharnogo diabeta 2 tipa [Pathogenetic role of intestinal dysbiosis in the development of obesity, insulin resistance and type 2 diabetes]. Zdorovia Ukrainy. Tematychnyi nomer. Hastroenterolohiia. Hepatolohiia. Koloproktolohiia. – Health of Ukraine. Thematic number. Gastroenterology. Hepatology. Coloproctology, 2 (40), 20-21 [in Russian].
Zhuravlova, L.V., & Shekhovtsova, Yu.O. (2014). Tsukrovyi diabet 2-ho typu ta khronichnyi pankreatyt: odna zaloza – dvi problemy [Type 2 diabetes mellitus and chronic pancreatitis: one gland – two problems]. Liky Ukrainy – Medicines of Ukraine, 9 (185), 11-14 [in Ukrainian].
Babinets, L.S., Nazarchuk, N.V., & Botsyuk, N.Ye. (2015). Trofolohichnyi status khvorykh na khronichnyi pankreatyt biliarnoho henezu [Trophological status of patients with chronic pancreatitis of biliary origin]. Zdobutky klinichnoi ta eksperymentalnoi medytsyny – Achievements of Clinical and Experimental Medicine, 1, 142-143 [in Ukrainian].
WHO: Global Database on Body Mass Index. Retrieved from: http://apps.who.int/bmi/index.jsp?introPage=intro_3.html
Khobzey, M.K., Hulchiy, M.V., & Mankovskyy, B.M. (2014). Tsukrovyi diabet 1 typu u molodykh liudei ta doroslykh [Type 1 diabetes mellitus in young people and adults]. Unifikovanyi klinichnyi protokol pervynnoi ta vtorynnoi (spetsializovanoi) medychnoi dopomohy – Unified Clinical Protocol of Primary and Secondary (Specialized) Medical Care, 71 [in Ukrainian].
Khobzey, M.K., Hulchiy, M.V., & Stepanenko, A.V. (2012). Tsukrovyi diabet 2 typu [Diabetes mellitus type 2]. Unifikovanyi klinichnyi protokol pervynnoi ta vtorynnoi (spetsializovanoi) medychnoi dopomohy – Unified Clinical Protocol of Primary and Secondary (Specialized) Medical Care, 118 [in Ukrainian].
Hulchiy, M.V., Matyukha, L.F., & Netyazhenko, V.Z. (2012). Tsukrovyi diabet 2 typu [Diabetes mellitus type 2]. Adaptovana klinichna nastanova, zasnovana na dokazakh – Adapted Clinical Guidelines Based on Evidence, 343 [in Ukrainian].
