ANALYSIS OF MORPHOLOGICAL CHANGES OF THE BLADDER IN WOMEN OF EARLY AND LATE MENOPAUSAL PERIODS DEPENDING ON HORMONES
DOI:
https://doi.org/10.11603/1811-2471.2020.v.i2.11312Keywords:
the morphology of the urinary bladder mucosa, early and late menopausal periods, progesterone, estradiolAbstract
Currently the dysuria in perimenopausal women is one of the most challenging issues in world health care. The close anatomical and functional relations of the female urinary system with reproductive organs and their neuroendocrine system cause the necessity of use of complex investigation methods of different pathologies including aging caused ones.
The aim – to study the morphological changes of the urinary bladder in women in early and late menopausal periods and their dependencies of the progesterone and estradiol levels.
Material and Methods. We studied the biopsy specimens of the urinary bladder mucosa taken from the trigon and lateral wall in 62 women. 20 patients were in early menopausal period, 28 were in late. 14 women 35–45 years old were in the control group. We use histological and the biochemical study methods.
Results. We proved that in case of dysuria in perimenopausal women there are the distinct dystrophic and degenerative alterations in the urinary bladder mucosa. They are accompanied by inflammatory reactions in lamina propria and compensatory hyperplastic processes. The hormones’ levels decreased progressively in both patients’ groups in comparison to the control group.
Conclusion. The decrease of hormones’ levels in women in early and late menopausal periods is directly corelated with the severity of morphology signs.
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