INFLUENCE OF PROBIOTIC-VITAMIN-MINERAL COMPLEX ON IMMUNOLOGICAL PARAMETERS AT OSTEOARTHRITIS AND EXCRETORY HYPOFUNCTION OF PANCREAS
DOI:
https://doi.org/10.11603/1811-2471.2020.v.i2.11310Keywords:
primary osteoarthritis, excretory insufficiency of the pancreas, immune status, probiotic-vitamin-mineral complexAbstract
Changes of the immunological status develop in patients at a combination of primary osteoarthritis and pancreatogenic excretory insufficiency of a pancreas.
The aim of the study – to improve the known method of treatment by additional administration to patients with primary osteoarthritis in combination with pancreatogenic exocrine insufficiency of the pancreas probiotic-vitamin-mineral complex aimed at correcting disorders in the immune status.
Material and Methods. 67 patients with primary osteoarthritis in combination with pancreatogenic exocrine pancreatic insufficiency were examined. Patients' immune status was assessed by levels of CD3, CD22, CD4 and CD8, CD16, Ig M, G, A and complement activity. Patients were divided into two groups: group 1 received protocol treatment, group 2 in addition to protocol treatment received a probiotic-vitamin-mineral complex.
Results and Discussion. The studied patients revealed the presence of secondary immune deficiency in the relative suppressor variant against the background of increasing levels of all studied classes of immunoglobulins, as well as a decrease in nonspecific resistance in the level of complement activity. After comprehensive treatment, the immunological status of patients improved statistically significantly in both groups, but in group 2 the therapeutic effect was more significant.
Conclusion. It was found that the use in the complex treatment of patients with primary osteoarthritis in combination with pancreatogenic exocrine insufficiency of the pancreas probiotic-vitamin-mineral complex Bion 3 according to the scheme of 1 tablet once a day for 6 weeks contributes to the normalization of immune status.
References
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