LIVER STRUCTURE’S REORGANIZATION, INDUCED BY MELPHALAN, AND ITS CORRECTION WITH GRANULOCYTE COLONY STIMULATING FACTOR AND ENTEROSORPTION
DOI:
https://doi.org/10.11603/1811-2471.2019.v.i4.10817Keywords:
melphalan, granulocyte colony stimulating factor, enterosorption, kidney structureAbstract
The aim of the work – to study structural changes of liver tissues in melphalan, granulocyte colony stimulating factor (G-CSF) biosimilars and enterosorption use.
Material and Methods. Histological examination of rats’ liver tissues was performed in melphalan, granulocyte colony stimulating factor and enterosorption use.
Results. It was proved that combination of granulocyte colony stimulating factor and enteral sorption therapy was the most efficient to improve the liver structure, which is disrupted because of melphalan injection.
Conclusions. Proved protective effects on the liver structure are the ground for further investigation of therapeutic capability of combination of granulocyte colony stimulating factor and enterosorption in anti-cancer chemotherapy.
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