ВПЛИВ ІНОЗИТОЛУ НА ОРГАНІЗМ ТА РЕПРОДУКТИВНУ ФУНКЦІЮ ЖІНКИ

С. В. Хміль; О. В. Денефіль; Н. Ю. Терлецька; М. С. Хміль; Н. Я. Петришин

doi:10.11603/1811-2471.2022.v.i4.13495

Автор(и)

С. В. Хміль Тернопільський національний медичний університет імені І. Я. Горбачевського МОЗ України
О. В. Денефіль Тернопільський національний медичний університет імені І. Я. Горбачевського МОЗ України
Н. Ю. Терлецька Тернопільський національний медичний університет імені І. Я. Горбачевського МОЗ України
М. С. Хміль Тернопільський національний медичний університет імені І. Я. Горбачевського МОЗ України
Н. Я. Петришин Тернопільський національний медичний університет імені І. Я. Горбачевського МОЗ України

DOI:

https://doi.org/10.11603/1811-2471.2022.v.i4.13495

Ключові слова:

інозитол, міо-інозитол, репродуктивна система, оваріальний резерв, фертильність жінки, інсулін, FT500 plus®

Анотація

РЕЗЮМЕ. Мета роботи – визначити склад, біологічну функцію інозитолу, вплив міо-інозитолу на організм жінки, репродуктивну функцію та лікування гінекологічних захворювань, роль у регуляції вуглеводневого та ліпідного обмінів.

Матеріал і методи. У дослідженні використано загальнонаукові методи дослідження: аналіз і синтез, індукція та дедукція, аналогія, абстрагування і конкретизація, системний аналіз, формалізація.

Результати. Під час виконання дослідження було проаналізовано 53 джерела сучасної вітчизняної та зарубіжної літератури щодо інозитолу, міо-інозитолу та впливу його на організм та репродуктивну систему жінки.

Висновки. Аналіз літературних джерел показав, що міо-інозитол є важливим мікронутрієнтом для профілактики та лікування гінекологічних захворювань на фоні глікемії; жіночого безпліддя, як у природній концепції так і в циклах допоміжних репродуктивних технологій.

Посилання

Turner, B.L., Papházy, M.J., Haygarth, P.M., & McKelvie, I.D. (2002). Inositol phosphates in the environment. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 357(1420), 449-469.

Khmil, M.S., Khmil-Dosvald, A.S., Khmil, S.V., & Pidhayna, I.Ya. (2018). Perspektyvy vykorystannya inozytolu v zhinok iz syndromom polikistoznykh yayechnykiv (ohlyad literatury) [Prospects for the use of inositol in women with polycystic ovary syndrome (literature review)]. Visnyk sotsialnoyi hihiyeny ta orhanizatsiyi okhorony zdorovya Ukrayiny – Herald of Social Hygiene and Health Care Organization of Ukraine, 4, 82-89 [in Ukrainian].

Gromova, O.A. Torshin, I.Yu., & Limanova, O.A. (2013). Perspektivy ispolzovaniya mio-inozitola u zhenshchin s polikistozom yaichnikov i insulinorezistentnostyu v programmakh pregravidarnoy podgotovki k ekstrakorporal'nomu oplodotvoreniyu [Prospects for the use of myo-inositol in women with polycystic ovaries and insulin resistance in the programs of preconception preparation for in vitro fertilization]. Effektivnaya farmakoterapiya – Effective Pharmacotherapy, 5(51), 12-23 [in Russian].

Limanova, O.A., Gromova, O.A., & Torshin, I.Yu. (2013). Sistematicheskiy analiz molekulyarno-fiziologicheskikh effektov mio-inozitola: dannyye molekulyarnoy biologii, eksperimentalnoy i klinicheskoy meditsiny [Systematic analysis of the molecular physiological effects of myo-inositol: data from molecular biology, experimental and clinical medicine] Effektivnaya farmakoterapiya – Effective Pharmacotherapy, 28, 4-12 [in Russian].

Chernukha, G.Ye., Kaprina, Ye.K., & Naydukova, A.A. (2015). Novyye vozmozhnosti korrektsii narusheniy funktsii reproduktivnoy sistemy pri sindrome polikistoznykh yaichnikov [New possibilities for correcting reproductive system dysfunctions in polycystic ovary syndrome]. Meditsinskiy sovet – Medical Advice, 9, 34-38 [in Russian].

Kalugina, L.V., & Yusko, T.I. (2018). Mio-inozitol: terapevticheskiye vozmozhnosti i pregravidarnaya podgotovka pri sindrome polikistoznykh yaichnikov [Myo-inositol: therapeutic possibilities and preconception preparation in polycystic ovary syndrome]. Reproduktivnaya endokrinologiya – Reproductive Endocrinology, 4, 42 [in Russian].

Garg, D., & Tal, R. (2016). Inositol treatment and ART outcomes in women with PCOS. International Journal of Endocrinology. DOI: 10.1155/2016/1979654.

Zheng, X., Liu, Z., & Zhang, Y. (2015). Relationship between myo-inositol supplementary and gestational diabetes mellitus: a meta-analysis. Medicine (Baltimo), 94(42).

Nosenko, O.M., Novikova, O.V., Nosenko, E.N., & Novykova, E.V. (2021). Inozytoly v reproduktyvniy medytsyni: ohlyad literatury [Inositols in reproductive medicine: a review of the literature] [in Ukrainian].

Syusyuka, V. G., Makurina, G. I., Sergienko, M. Yu., Chornenka, A. S., & Kolokot, N. G. (2022). Diagnosis of hyperandrogenism in women of reproductive age. In The 4th International scientific and practical conference "Discussion and development of modern scientific research" (October 18-21, 2022). Helsinki, Finland. International Science Group, 2022, 487 p. (p. 274).

Benelli, E., Del Ghianda, S., & Di Cosmo C. (2016). A combined therapy with myo-inositol and d-chiro-inositol improves endocrine parameters and insulin resistance in PCOS young overweight women. International Journal of Endocrinology. DOI: 10.1155/2016/3204083.

Islamova, H.O. (2020). Pregravidarna pidhotovka zhinok iz syndromom polikistoznykh yayechnykiv [Pre-pregnancy preparation of women with polycystic ovary syndrome]. REPRODUCTIVE ENDOCRINOLOGY, 53, 30-34 [in Ukrainian].

Hadjiconstantinou, M., Mani, H., & Patel, N. (2017). Understanding and supporting women with polycystic ovary syndrome: a qualitative study in an ethnically diverse UK sample. Endocrine Connections, 6, 323-330.

Nosenko, O.M., & Novikova, O.V. (2020). Inositols in reproductive medicine. REPRODUCTIVE ENDOCRINOLOGY, 56, 23-34.

Nochvina, O., & Slyvka, Ye. (2021). Rol inozytu ta yoho izomeriv u metabolizmi hlyukozy: ohlyad literatury [The role of inositol and its isomers in glucose metabolism: a review of the literature]. Reproduktyvna endokrynolohiya – Reproductive Endocrinology, 62, 104-109. DOI: 10.18370/2309-4117.2021.62.104-109 [in Ukrainian].

Tsypkun, A.H. (2015). Farmakolohichna kharakterystyka ta zastosuvannya mioinozytolu v hinekolohichniy praktytsi [Pharmacological characteristics and use of myo-inositol in gynecological practice]. Reproduktyvna endokrynolohiya – Reproductive Endocrinology, (25), 28-30. DOI: 10.18370/2309-4117.2015.25.28-30 [in Ukrainian].

Berridge, M.J., & Irvine, R.F. (1989). Inositol phosphate and cell signaling. Nature, 36, 197-205.

Zaychenko, H.V. Rol inozytoliv u menedzhmenti syndromu polikistoznykh yayechnykiv zalezhno vid reproduktyvnykh planiv zhinky [The role of inositols in the management of polycystic ovary syndrome depending on a woman's reproductive plans] [in Ukrainian].

Papaleo, E., Unfer, V., & Baillargeon, J.P. (2009). Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial. Fertil. Steril., 91(5), 1750-1754. DOI: 10.1016/j.fertnstert.2008.01.088.

Simi, G., Genazzani, A.R., & Obino, M.E. (2017). Inositol and In Vitro Fertilization with Embryo Transfer. Int. J. Endocrinol., 2017, 5. Article ID 5469409. DOI: 10.1155/2017/ 5469409.

Teede, H.J., Misso, M.L., & Costello, M.F. (2018). International PCOS Network. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Hum. Reprod., 33(9), 1602-1618. DOI: 10.1093/humrep/dey256.

Khmil, S. V., & Kulyk, I. I. (2020). Efektyvnist skleroterapii ta prehravidarnoi pidhotovky u zhinok iz bezpliddiam na tli endometriozu [Effectiveness of sclerotherapy and pregravidary preparation in women with fertility due to endometriosis] Visnyk medychnykh i biolohichnykh doslidzhen – Bulletin of Medical and Biological Research, 4, 89-96 [in Ukrainian].

Khmil, S.V., Kulyk, I.I., & Mykula, R.P. (2018). Antyoksydantna terapiya u zhinok iz bezpliddyam na foni endometriozu [Antioxidant therapy in women with infertility due to endometriosis]. Visnyk sotsialnoyi hihiyeny ta orhanizatsiyi okhorony zdorovya Ukrayiny – Herald of Social Hygiene and Health Care Organizations of Ukraine, 4, 56-63 [in Ukrainian].

Chiu, T.T., Rogers, M.S., & Law, E.L. (2002): Follicular fluid and serum concentration of myo-inositol in patients undergoing IVF: relationship with oocyte quality. Hum. Reprod., 6(17) 1591-1596.

Genazzani, A.D., Lanzoni, C., Ricchieri, F., & Jasonni, V.M. (2008). Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome. Gynecol. Endocrinol., 24(3), 139-144. DOI: 10.1080/09513590801893232.

Zinchenko, V.H. (2022). Syndrom polikistoznykh yayechnykiv u divchat-pidlitkiv pubertatnoho periodu: diahnostyka ta taktyka likuvannia [Polycystic ovary syndrome in adolescent girls in the pubertal period: diagnosis and treatment tactics] [in Ukrainian].

D'Anna, R., Di Benedetto, V., & Rizzo, P. (2012). Myo-inositol may prevent gestational diabetes in PCOS women. Gynecol. Endocrinol., 28(6), 440-442. DOI: 10.3109/ 09513590.2011.633665.

Gerli, S., Mignosa, M., & Di Renzo, G.C. (2003). Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial. Eur. Rev. Med. Pharmacol. Sci., 7(6), 151-159.

Papaleo, E., Unfer, V., & Baillargeon, J.P. (2007). Myo-inositol in patients with polycystic ovary syndrome: a novel method for ovulation induction. Gynecol. Endocrinol., 23(12), 700-703. DOI: 10.1080/09513590701672405.

Ciotta, L., Stracquadanio, M., & Pagano, I. (2011). Effects of myo-inositol supplementation on oocyte's quality in PCOS patients: a double-blind trial. Eur. Rev. Med. Pharmacol. Sci., 15(5), 509-514.

Pacchiarotti, A., Carlomagno, G., Antonini, G., & Pacchiarotti, A. (2016). Effect of myo-inositol and melatonin versus myo-inositol, in a randomized controlled trial, for improving in vitro fertilization of patients with polycystic ovarian syndrome. Gynecological Endocrinology, 32(1), 69-73.

(2016). Act of myo-inositol and melatonin versus myo-inositol, in a randomized controlled trial, for improving in vitro fertilization of patients with polycystic ovarian syndrome. Gynecol Endocrinol., 32(1), 69-73. DOI: 10.3109/ 09513590.2015.1101444.

Lisi, F., Carfagna, P., & Oliva, M.M. (2012). Pretreatment with myo-inositol in non-polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study. Reprod. Biol. Endocrinol., 10, 52. DOI: 10.1186/1477-7827-10-52.

Galletta, M., Grasso, S., Vaiarelli, A., & Roseff, S.J. (2011). Bye-bye chiro-inositol – myo-inositol: true progress in the treatment of polycystic ovary syndrome and ovulation induction. Eur. Rev. Med. Pharmacol. Sci., 15(10), 1212-1214.

Rizzo, P., Raffone, E., & Benedetto, V. (2010). Effect of the treatment with МІ-inositol plus folic acid plus melatonin in comparison with a treatment with МІ-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles. A prospective, clinical trial. Eur. Rev. Med. Pharmacol. Sci., 14, 555-561.

Alviggi, C., Cariati, F., Conforti, A., De Rosa, P., Vallone, R., Strina, I., ... & De Placido, G. (2016). The effect of FT500 Plus® on ovarian stimulation in PCOS women. Reproductive Toxicology, 59, 40-44.

Skoreyko, R.S. (2022). Porushennia menstrualnoyi funktsii u zhinok rannioho reproduktyvnoho viku iz ozhyrinniam: prohnozuvannia ta taktyka likuvannia [Disorders of menstrual function in women of early reproductive age with obesity: prognosis and treatment tactics] [in Ukrainian].

Chiu, T.T., Rogers, M.S., Law, E.L., Briton-Jones, C.M., Cheung, L.P., & Haines, C.J. (2002). Follicular fluid and serum concentrations of myo-inositol in patients undergoing IVF: relationship with oocyte quality. Hum. Reprod., 17(6), 1591-1596. DOI: 10.1093/humrep/17.6.1591.

Chiu, T.T., Rogers, M.S., Briton-Jones, C., & Haines, C. (2003). Effects of myo-inositol on the in-vitro maturation and subsequent development of mouse oocytes. Hum. Reprod.,18(2), 408-416. DOI: 10.1093/humrep/deg113.

Unfer, V., Carlomagno, G., Rizzo, P., Raffone, E., & Roseff, S. (2011). Myo-inositol rather than D-chiroinositol is able to improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial. Eur. Rev. Med. Pharmacol. Sci., 15(4), 452-457. PMID: 21608442.

Brusco, G.F., & Mariani, M. (2013). Inositol: effects on oocyte quality in patients undergoing ICSI. An open study. Eur. Rev. Med. Pharmacol. Sci., 17(22), 3095-3102. PMID:24302192.

Tao, Y., Chen, H., Tian, N.N., Huo, D.T., Li, G., Zhang, Y.H. (2010). Effects of L-ascorbic acid, alphatocopherol and co-culture on in vitro developmental potential of porcine cumulus cells free oocytes. Reprod. Domest. Anim., 45(1), 19-25. DOI: 10.1111/j.1439-0531.2008.01129.x. RDA1129.

Henmi, H., Endo, T., Kitajima, Y., Manase, K., Hata, H., & Kudo, R. (2003). Effects of ascorbic acid supplementation on serum progesterone levels in patients with a luteal phase defect. Fertil. Steril., 80(2), 459-461. DOI: S0015028203006575.

Ozkaya, M.O., & Naziroglu, M. (2010). Multivitamin and mineral supplementation modulates oxidative stress and antioxidant vitamin levels in serum and follicular fluid of women undergoing in vitro fertilization. Fertil. Steril., 94(6), 2465-2466. DOI: S0015-0282(10)00141-X [PII] 10.1016/j.fertnstert.2010.01.066.

Berker, B., Kaya, C., Aytac, R., & Satiroglu, H. (2009). Homocysteine concentrations in follicular fluid are associated with poor oocyte and embryo qualities in polycystic ovary syndrome patients undergoing assisted reproduction. Hum. Reprod., 24(9), 2293-2302. DOI: dep069 [PII] 10.1093/humrep/dep069.

Paszkowski, T., Traub, A.I., Robinson, S.Y., McMaster, D. (1995). Selenium dependent glutathione peroxidase activity in human follicular fluid. Clin. Chim. Acta., 236(2), 173-180. DOI: 0009898195981309 [PII].

Kim, A.M., Vogt, S., O'Halloran, T.V., & Woodruff, T.K. (2010). Zinc availability regulates exit from meiosis in maturing mammalian oocytes. Nat. Chem. Biol., 6(9), 674-681. DOI: nchembio.419 [PII] 10.1038/nchembio.419.

Cetin, I., Berti, C., & Calabrese, S. (2010). Role of micronutrients in the periconceptional period. Hum. Reprod. Update, 16(1), 80-95. DOI: dmp025 [PII] 10.1093/humupd/dmp025.

DeLeo, V., LaMarca, A., & Cappelli, V. Etal (2012). Evaluation of the treatment with D-chiro-inositol on levels of oxidative stress in pcos patients. Minerva Ginecol., 64(6), 531-538.

Unfer, V., Carlomagno, G., & Dante, G. Etal (2012). Effects of myoinositol in women with PCOS: a systematic review of randomized controlled trials. Gynecol. Endocrinol., 28(7), 509-515.

Khmil, S.V., & Khmil, M.S. (2018). Optymizatsiya kompleksnoyi prehravidarnoyi pidhotovky ta protokoliv kontrolovanoyi stymulyatsiyi ovulyatsiyi v patsiyentok iz syndromom polikistoznykh yayechnykiv u prohramakh dopomizhnykh reproduktyvnykh tekhnolohiy [Optimization of complex pre-gravid preparation and protocols of controlled stimulation of ovulation in patients with polycystic ovary syndrome in programs of assisted reproductive technologies]. Visnyk naukovykh doslidzhen – Herald of Scientific Research, 4, 108-113 [in Ukrainian].

Kamenov, Z., Kolarov, G., & Gatva, A. (2015). Induktsiya ovulyatsii mio-inozitolom, otdelno i v sochetanii s tsitratom klomifena pri sindrome polikistoznykh yaichnikov s insulino rezistentnostyu [Ovulation induction with myo-inositol alone and in combination with clomiphene citrate in polycystic ovary syndrome with insulin resistance]. Ginekologicheskaya endokrinologiya – Gynecological Endocrinology, 31(2), 131-138 [in Russian].